Antiviral Treatments

Michael G. Ison

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


Most viral respiratory tract infections are caused by classic respiratory viruses, including influenza, respiratory syncytial virus, human metapneumovirus, parainfluenza, rhinovirus, and adenovirus, whereas other viruses, such as herpes simplex, cytomegalovirus, and measles virus, can opportunistically affect the respiratory tract. The M2 inhibitors, amantadine and rimantadine, were historically effective for the prevention and treatment of influenza A but all circulating strains are currently resistant to these drugs. Neuraminidase inhibitors are the sole approved class of antivirals to treat influenza. Ribavirin, especially when combined with intravenous antibody, reduces morbidity and mortality among immunosuppressed patients.

Original languageEnglish (US)
Pages (from-to)139-153
Number of pages15
JournalClinics in Chest Medicine
Issue number1
StatePublished - Mar 1 2017


  • Influenza
  • Neuraminidase inhibitor
  • Respiratory syncytial virus (RSV)
  • Respiratory virus
  • Ribavirin

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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