Antiviral Treatments

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Most viral respiratory tract infections are caused by classic respiratory viruses, including influenza, respiratory syncytial virus, human metapneumovirus, parainfluenza, rhinovirus, and adenovirus, whereas other viruses, such as herpes simplex, cytomegalovirus, and measles virus, can opportunistically affect the respiratory tract. The M2 inhibitors, amantadine and rimantadine, were historically effective for the prevention and treatment of influenza A but all circulating strains are currently resistant to these drugs. Neuraminidase inhibitors are the sole approved class of antivirals to treat influenza. Ribavirin, especially when combined with intravenous antibody, reduces morbidity and mortality among immunosuppressed patients.

Original languageEnglish (US)
Pages (from-to)139-153
Number of pages15
JournalClinics in Chest Medicine
Volume38
Issue number1
DOIs
StatePublished - Mar 1 2017

Fingerprint

Human Influenza
Antiviral Agents
Rimantadine
Metapneumovirus
Paramyxoviridae Infections
Amantadine
Rhinovirus
Measles virus
Respiratory Syncytial Viruses
Ribavirin
Intravenous Immunoglobulins
Neuraminidase
Simplexvirus
Orthomyxoviridae
Cytomegalovirus
Adenoviridae
Respiratory Tract Infections
Respiratory System
Viruses
Morbidity

Keywords

  • Influenza
  • Neuraminidase inhibitor
  • Respiratory syncytial virus (RSV)
  • Respiratory virus
  • Ribavirin

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Ison, Michael G. / Antiviral Treatments. In: Clinics in Chest Medicine. 2017 ; Vol. 38, No. 1. pp. 139-153.
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Antiviral Treatments. / Ison, Michael G.

In: Clinics in Chest Medicine, Vol. 38, No. 1, 01.03.2017, p. 139-153.

Research output: Contribution to journalReview article

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