Antral follicle count is increased in obese women placed on oral contraceptive pills

April K. Parker, Natalia M. Grindler, Emily S. Jungheim, Randall R. Odem, Valerie S. Ratts, Amber R. Cooper*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

OBJECTIVE: To determine the effect of short-term combined oral contraceptive (OCP) use on antral follicle count (AFC) in obese and nonobese women with infertility. STUDY DESIGN: A retrospective review of women who had an AFC (sum of 2– 10 mm bilateral ovarian follicles on basal follicular phase ultrasound) measured before and after short-term OCP use between the years 2005 and 2010. These were women who had a baseline AFC measurement during an unsuccessful controlled ovarian hyperstimulation/intrauterine insemination who were then placed on OCPs prior to an in vitro fertilization (IVF) cycle that included a subsequent AFC measurement at baseline. RESULTS: A total of 57 IVF cycles met criteria for inclusion in the study. AFC was not impacted by OCP use in the nonobese cohort (BMI <30). Baseline AFC in obese women (BMI ≥ 30), however, increased after OCP use (18±6 vs. 28±9, p=0.002). CONCLUSION: Use of suppressive medications like OCPs in obese women increases AFC during IVF, potentially by AFC cohort synchrony. This observation warrants consideration when using AFC to predict gonadotropin/ART response as well as future prospective research to further elucidate potential etiologies.

Original languageEnglish (US)
Pages (from-to)155-159
Number of pages5
JournalJournal of Reproductive Medicine
Volume60
Issue number2
StatePublished - Apr 2015
Externally publishedYes

Keywords

  • Antral follicle count
  • BMI
  • Body mass index
  • IVF
  • In vitro fertilization
  • Infertility
  • Obesity
  • Ovarian suppression

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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