Aortic relative pressure components derived from four-dimensional flow cardiovascular magnetic resonance

Pablo Lamata, Alex Pitcher, Sebastian Krittian, David Nordsletten, Malenka M. Bissell, Thomas Cassar, Alex J. Barker, Michael Markl, Stefan Neubauer, Nicolas P. Smith*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Purpose: To describe the assessment of the spatiotemporal distribution of relative aortic pressure quantifying the magnitude of its three major components. Methods: Nine healthy volunteers and three patients with aortic disease (bicuspid aortic valve, dissection, and Marfan syndrome) underwent 4D-flow CMR. Spatiotemporal pressure maps were computed from the CMR flow fields solving the pressure Poisson equation. The individual components of pressure were separated into time-varying inertial ("transient"), spatially varying inertial ("convective"), and viscous components. Results: Relative aortic pressure is primarily caused by transient effects followed by the convective and small viscous contributions (64.5, 13.6, and 0.3 mmHg/m, respectively, in healthy subjects), although regional analysis revealed prevalent convective effects in specific contexts, e.g., Sinus of Valsalva and aortic arch at instants of peak velocity. Patients showed differences in peak transient values and duration, and localized abrupt convective changes explained by abnormalities in aortic geometry, including the presence of an aneurysm, a pseudo-coarctation, the inlet of a dissection, or by complex flow patterns. Conclusion: The evaluation of the three components of relative pressure enables the quantification of mechanistic information for understanding and stratifying aortic disease, with potential future implications for guiding therapy.

Original languageEnglish (US)
Pages (from-to)1162-1169
Number of pages8
JournalMagnetic resonance in medicine
Issue number4
StatePublished - Oct 2014


  • Aorta
  • Blood pressure
  • Cardiac magnetic resonance imaging
  • Hemodynamics
  • Noninvasive pressure estimation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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