APC/C-Cdh1: From cell cycle to cellular differentiation and genomic integrity

Xinxian Qiao; Liyong Zhang; Armin M. Gamper; Takeo Fujita; Yong Wan

doi:10.4161/cc.9.19.13585

APC/C-Cdh1: From cell cycle to cellular differentiation and genomic integrity

Xinxian Qiao, Liyong Zhang, Armin M. Gamper, Takeo Fujita, Yong Wan^*

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Review article › peer-review

75 Scopus citations

Abstract

Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets various substrates for proteolysis inside and outside of the cell cycle. The activation of APC/C is dependent on two wD-40 domain proteins, Cdc20 and Cdh1. while APC/Cdc20 principally regulates mitotic progression, APC/Cdh1 shows a broad spectrum of substrates in and beyond cell cycle. in the past several years, numerous biochemical and mouse genetic studies have greatly attracted our attention to the emerging role of APC/Cdh1 in genomic integrity, cellular differentiation and human diseases. This review will aim to summarize the recently expanded understanding of APC/Cdh1 in regulating biological function and how its dysfunction may lead to diseases.

Original language	English (US)
Pages (from-to)	3904-3912
Number of pages	9
Journal	Cell Cycle
Volume	9
Issue number	19
DOIs	https://doi.org/10.4161/cc.9.19.13585
State	Published - Oct 1 2010

Keywords

APC/C
Cdh1
Differentiation
Genomic integrity
Proteolysis
Signal transduction
Tumorigenesis

ASJC Scopus subject areas

Molecular Biology
Cell Biology
Developmental Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.4161/cc.9.19.13585

Cite this

@article{e9db9c76b2d6451cbd66989f405c4dcb,

title = "APC/C-Cdh1: From cell cycle to cellular differentiation and genomic integrity",

abstract = "Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets various substrates for proteolysis inside and outside of the cell cycle. The activation of APC/C is dependent on two wD-40 domain proteins, Cdc20 and Cdh1. while APC/Cdc20 principally regulates mitotic progression, APC/Cdh1 shows a broad spectrum of substrates in and beyond cell cycle. in the past several years, numerous biochemical and mouse genetic studies have greatly attracted our attention to the emerging role of APC/Cdh1 in genomic integrity, cellular differentiation and human diseases. This review will aim to summarize the recently expanded understanding of APC/Cdh1 in regulating biological function and how its dysfunction may lead to diseases.",

keywords = "APC/C, Cdh1, Differentiation, Genomic integrity, Proteolysis, Signal transduction, Tumorigenesis",

author = "Xinxian Qiao and Liyong Zhang and Gamper, {Armin M.} and Takeo Fujita and Yong Wan",

note = "Funding Information: The laboratory work is kindly supported by NIH grant CA115943. Y. Wan is a scholar of the American Cancer Society.",

year = "2010",

month = oct,

day = "1",

doi = "10.4161/cc.9.19.13585",

language = "English (US)",

volume = "9",

pages = "3904--3912",

journal = "Cell Cycle",

issn = "1538-4101",

publisher = "Landes Bioscience",

number = "19",

}

TY - JOUR

T1 - APC/C-Cdh1

T2 - From cell cycle to cellular differentiation and genomic integrity

AU - Qiao, Xinxian

AU - Zhang, Liyong

AU - Gamper, Armin M.

AU - Fujita, Takeo

AU - Wan, Yong

N1 - Funding Information: The laboratory work is kindly supported by NIH grant CA115943. Y. Wan is a scholar of the American Cancer Society.

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets various substrates for proteolysis inside and outside of the cell cycle. The activation of APC/C is dependent on two wD-40 domain proteins, Cdc20 and Cdh1. while APC/Cdc20 principally regulates mitotic progression, APC/Cdh1 shows a broad spectrum of substrates in and beyond cell cycle. in the past several years, numerous biochemical and mouse genetic studies have greatly attracted our attention to the emerging role of APC/Cdh1 in genomic integrity, cellular differentiation and human diseases. This review will aim to summarize the recently expanded understanding of APC/Cdh1 in regulating biological function and how its dysfunction may lead to diseases.

AB - Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets various substrates for proteolysis inside and outside of the cell cycle. The activation of APC/C is dependent on two wD-40 domain proteins, Cdc20 and Cdh1. while APC/Cdc20 principally regulates mitotic progression, APC/Cdh1 shows a broad spectrum of substrates in and beyond cell cycle. in the past several years, numerous biochemical and mouse genetic studies have greatly attracted our attention to the emerging role of APC/Cdh1 in genomic integrity, cellular differentiation and human diseases. This review will aim to summarize the recently expanded understanding of APC/Cdh1 in regulating biological function and how its dysfunction may lead to diseases.

KW - APC/C

KW - Cdh1

KW - Differentiation

KW - Genomic integrity

KW - Proteolysis

KW - Signal transduction

KW - Tumorigenesis

UR - http://www.scopus.com/inward/record.url?scp=77958465476&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77958465476&partnerID=8YFLogxK

U2 - 10.4161/cc.9.19.13585

DO - 10.4161/cc.9.19.13585

M3 - Review article

C2 - 20935501

AN - SCOPUS:77958465476

SN - 1538-4101

VL - 9

SP - 3904

EP - 3912

JO - Cell Cycle

JF - Cell Cycle

IS - 19

ER -

APC/C-Cdh1: From cell cycle to cellular differentiation and genomic integrity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this