APC/C-Cdh1: From cell cycle to cellular differentiation and genomic integrity

Xinxian Qiao, Liyong Zhang, Armin M. Gamper, Takeo Fujita, Yong Wan*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations

Abstract

Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets various substrates for proteolysis inside and outside of the cell cycle. The activation of APC/C is dependent on two wD-40 domain proteins, Cdc20 and Cdh1. while APC/Cdc20 principally regulates mitotic progression, APC/Cdh1 shows a broad spectrum of substrates in and beyond cell cycle. in the past several years, numerous biochemical and mouse genetic studies have greatly attracted our attention to the emerging role of APC/Cdh1 in genomic integrity, cellular differentiation and human diseases. This review will aim to summarize the recently expanded understanding of APC/Cdh1 in regulating biological function and how its dysfunction may lead to diseases.

Original languageEnglish (US)
Pages (from-to)3904-3912
Number of pages9
JournalCell Cycle
Volume9
Issue number19
DOIs
StatePublished - Oct 1 2010

Keywords

  • APC/C
  • Cdh1
  • Differentiation
  • Genomic integrity
  • Proteolysis
  • Signal transduction
  • Tumorigenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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