Aphagia and adipsia after preferential destruction of nerve cell bodies in hypothalamus

Sebastian P. Grossman*, Dennis Dacey, Angelos E. Halaris, Timothy Collier, Aryeh Routtenberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

148 Scopus citations

Abstract

Microinjections of the excitatory neurotoxin kainic acid into the lateral hypothalamus of rats produced a period of aphagia and adipsia. Kainate-treated rats displayed transient motor effects during the first hours after the injection but did not show the persisting sensory-motor and arousal disturbances typically observed in animals with electrolytic lesions in this part of the hypothalamus. Histological examination revealed a significant reduction in the number of nerve cell bodies in the lateral hypothalamus. Silver-stained material indicated no evidence of damage to fiber systems passing through the affected region. Assays of dopamine in hypothalamus, striatum, and telencephalon did not indicate significant differences between experimental and control animals. These results are in agreement with recent reports of the anatomical and biochemical effects of intracerebral kainic acid injections and suggest that the observed effect on feeding behavior is related to the destruction of neurons in the lateral hypothalamus.

Original languageEnglish (US)
Pages (from-to)537-539
Number of pages3
JournalScience
Volume202
Issue number4367
DOIs
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • General

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