Apnea in a child after oral codeine: A genetic variant - An ultra-rapid metabolizer

Polina Voronov; Henry J. Przybylo; Narasimhan Jagannathan

doi:10.1111/j.1460-9592.2006.02182.x

Apnea in a child after oral codeine: A genetic variant - An ultra-rapid metabolizer

Polina Voronov^*, Henry J. Przybylo, Narasimhan Jagannathan

^*Corresponding author for this work

Anesthesiology

Research output: Contribution to journal › Article › peer-review

147 Scopus citations

Abstract

We present a case of a 29 months old previously healthy child who experienced apnea resulting in brain injury following a dose of acetaminophen and codeine 2 days after an uneventful anesthetic for tonsillectomy. A genetic polymorphism leading to ultra-rapid metabolism of codeine into morphine resulted in narcosis and apnea. This paper discusses the use of codeine for pain relief, obstructive sleep apnea, the alteration of the CYP2D6 gene and the resulting effect on drug metabolism.

Original language	English (US)
Pages (from-to)	684-687
Number of pages	4
Journal	Paediatric Anaesthesia
Volume	17
Issue number	7
DOIs	https://doi.org/10.1111/j.1460-9592.2006.02182.x
State	Published - Jul 1 2007

Keywords

Apnea
Codeine
Complications
Genetic polymorphism
Obstructive sleep apnea
Pediatrics

ASJC Scopus subject areas

Anesthesiology and Pain Medicine
Pediatrics, Perinatology, and Child Health

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10.1111/j.1460-9592.2006.02182.x

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abstract = "We present a case of a 29 months old previously healthy child who experienced apnea resulting in brain injury following a dose of acetaminophen and codeine 2 days after an uneventful anesthetic for tonsillectomy. A genetic polymorphism leading to ultra-rapid metabolism of codeine into morphine resulted in narcosis and apnea. This paper discusses the use of codeine for pain relief, obstructive sleep apnea, the alteration of the CYP2D6 gene and the resulting effect on drug metabolism.",

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AB - We present a case of a 29 months old previously healthy child who experienced apnea resulting in brain injury following a dose of acetaminophen and codeine 2 days after an uneventful anesthetic for tonsillectomy. A genetic polymorphism leading to ultra-rapid metabolism of codeine into morphine resulted in narcosis and apnea. This paper discusses the use of codeine for pain relief, obstructive sleep apnea, the alteration of the CYP2D6 gene and the resulting effect on drug metabolism.

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KW - Complications

KW - Genetic polymorphism

KW - Obstructive sleep apnea

KW - Pediatrics

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Apnea in a child after oral codeine: A genetic variant - An ultra-rapid metabolizer

Abstract

Keywords

ASJC Scopus subject areas

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