Apnea in a child after oral codeine

A genetic variant - An ultra-rapid metabolizer

Polina Voronov*, Henry J. Przybylo, Narasimhan Jagannathan

*Corresponding author for this work

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

We present a case of a 29 months old previously healthy child who experienced apnea resulting in brain injury following a dose of acetaminophen and codeine 2 days after an uneventful anesthetic for tonsillectomy. A genetic polymorphism leading to ultra-rapid metabolism of codeine into morphine resulted in narcosis and apnea. This paper discusses the use of codeine for pain relief, obstructive sleep apnea, the alteration of the CYP2D6 gene and the resulting effect on drug metabolism.

Original languageEnglish (US)
Pages (from-to)684-687
Number of pages4
JournalPaediatric Anaesthesia
Volume17
Issue number7
DOIs
StatePublished - Jul 1 2007

Fingerprint

Codeine
Apnea
Stupor
Cytochrome P-450 CYP2D6
Tonsillectomy
Obstructive Sleep Apnea
Genetic Polymorphisms
Brain Injuries
Morphine
Anesthetics
Pain
Genes
codeine drug combination acetaminophen
Metabolic Side Effects of Drugs and Substances

Keywords

  • Apnea
  • Codeine
  • Complications
  • Genetic polymorphism
  • Obstructive sleep apnea
  • Pediatrics

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

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abstract = "We present a case of a 29 months old previously healthy child who experienced apnea resulting in brain injury following a dose of acetaminophen and codeine 2 days after an uneventful anesthetic for tonsillectomy. A genetic polymorphism leading to ultra-rapid metabolism of codeine into morphine resulted in narcosis and apnea. This paper discusses the use of codeine for pain relief, obstructive sleep apnea, the alteration of the CYP2D6 gene and the resulting effect on drug metabolism.",
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Apnea in a child after oral codeine : A genetic variant - An ultra-rapid metabolizer. / Voronov, Polina; Przybylo, Henry J.; Jagannathan, Narasimhan.

In: Paediatric Anaesthesia, Vol. 17, No. 7, 01.07.2007, p. 684-687.

Research output: Contribution to journalArticle

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