APOL1-Associated End-Stage Renal Disease in a Living Kidney Transplant Donor

N. A. Zwang, A. Shetty, N. Sustento-Reodica, E. J. Gordon, J. Leventhal, L. Gallon, J. J. Friedewald*

*Corresponding author for this work

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Homozygosity for apolipoprotein-L1 (APOL1) risk variants has emerged as an important predictor of renal disease in individuals of African descent over the past several years. Additionally, these risk variants may be important predictors of renal allograft failure when present in a living or deceased donor. Currently, there is no universal recommendation for screening of potential donors. We present a case of end-stage renal disease with focal segmental glomerulosclerosis in a living donor 7 years following donor nephrectomy. Genetic assessment revealed homozygosity for the G1 high-risk APOL1 variant.

Original languageEnglish (US)
Pages (from-to)3568-3572
Number of pages5
JournalAmerican Journal of Transplantation
Volume16
Issue number12
DOIs
StatePublished - Dec 1 2016

Fingerprint

Apolipoproteins
Chronic Kidney Failure
Tissue Donors
Kidney
Donor Selection
Focal Segmental Glomerulosclerosis
Living Donors
Nephrectomy
Renal Insufficiency
Allografts

Keywords

  • clinical research/practice
  • donor nephrectomy
  • donors and donation: donor follow-up
  • donors and donation: living
  • kidney transplantation/nephrology
  • organ transplantation in general
  • pathology/histopathology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

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abstract = "Homozygosity for apolipoprotein-L1 (APOL1) risk variants has emerged as an important predictor of renal disease in individuals of African descent over the past several years. Additionally, these risk variants may be important predictors of renal allograft failure when present in a living or deceased donor. Currently, there is no universal recommendation for screening of potential donors. We present a case of end-stage renal disease with focal segmental glomerulosclerosis in a living donor 7 years following donor nephrectomy. Genetic assessment revealed homozygosity for the G1 high-risk APOL1 variant.",
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AU - Zwang, N. A.

AU - Shetty, A.

AU - Sustento-Reodica, N.

AU - Gordon, E. J.

AU - Leventhal, J.

AU - Gallon, L.

AU - Friedewald, J. J.

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