TY - JOUR
T1 - Apolipoprotein E affects serial changes in total and low-density lipoprotein cholesterol in adolescent girls
T2 - Project HeartBeat!
AU - Fulton, Janet E.
AU - Dai, Shifan
AU - Grunbaum, Jo Anne
AU - Boerwinkle, Eric
AU - Labarthe, Darwin R.
N1 - Funding Information:
From the School of Public Health and the Institute of Molecular Medicine, The University of Texas-Houston, Health Science Cente~ Houston, TX. Submitted January 23, 1998; accepted September 11, 1998. Supported by the National Heart, Lung and Blood Institute, the Centers for Disease Control and Prevention (through the Southwest Center for Prevention Research, U48/CCU609653), Compaq Computer Corporation, and the University of Texas-Houston, Health Science Center, School of Public Health. Address reprint requests to Janet E. Fulton, PhD, Centers for Disease Control and Prevention, Division of Nutrition and Physical Activity, 4770 Buford Hwy, NE, Mailstop K-46, Atlanta, GA 30341-3724. Copyright © 1999 by W.B. Saunders Company 0026-0495/99/4803-000351 O. 00/0
PY - 1999
Y1 - 1999
N2 - Apolipoprotein E (apo E) polymorphism is a genetic determinant of lipid and lipoprotein levels and the risk for coronary heart disease. The extent to which serial patterns of change in total cholesterol and low-density lipoprotein cholesterol (LDL-C) concentrations varied by apo E genotype was therefore investigated in 247 Caucasian girls aged 8 to 14 at baseline who were participating in Project HeartBeat!, a mixed longitudinal study of cardiovascular disease (CVD) risk factor development in children. Plasma lipid concentrations were determined for each participant three times per year (every 4 months) for up to 4 years from October 1991 through August 1995. Mean total cholesterol values for individuals with ε2/3, ε3/3, and ε3/4 genotypes were 141.7, 161.6, and 165.9 mg/dL, respectively (P < .001). Corresponding LDL-C values for individuals with ε2/3, ε3/3, and ε3/4 genotypes were 74.6, 94.8, and 98.7 mg/dL, respectively (P < .001). The results of longitudinal modeling indicated that age trajectories for total cholesterol and LDL-C varied significantly by apo E genotype. Individuals with ε3/3 and ε3/4 genotypes exhibited similar patterns of change in total cholesterol and LDL-C from ages 8 to 18, while individuals with the ε2/3 genotype demonstrated a significantly different pattern of change (age2 x genotype interaction, P < .05). For example, individuals with the ε2/3 genotype showed a slight increase in total cholesterol from approximately 141 to 146 mg/dL from ages 8 to 10; total cholesterol then decreased monotonically from ages 10 to 18 from 146 to 115 mg/dL. The apo E effect on total cholesterol and LDL-C and their change during adolescence is strong and may be modified by factors affecting growth, maturation, and reproductive function.
AB - Apolipoprotein E (apo E) polymorphism is a genetic determinant of lipid and lipoprotein levels and the risk for coronary heart disease. The extent to which serial patterns of change in total cholesterol and low-density lipoprotein cholesterol (LDL-C) concentrations varied by apo E genotype was therefore investigated in 247 Caucasian girls aged 8 to 14 at baseline who were participating in Project HeartBeat!, a mixed longitudinal study of cardiovascular disease (CVD) risk factor development in children. Plasma lipid concentrations were determined for each participant three times per year (every 4 months) for up to 4 years from October 1991 through August 1995. Mean total cholesterol values for individuals with ε2/3, ε3/3, and ε3/4 genotypes were 141.7, 161.6, and 165.9 mg/dL, respectively (P < .001). Corresponding LDL-C values for individuals with ε2/3, ε3/3, and ε3/4 genotypes were 74.6, 94.8, and 98.7 mg/dL, respectively (P < .001). The results of longitudinal modeling indicated that age trajectories for total cholesterol and LDL-C varied significantly by apo E genotype. Individuals with ε3/3 and ε3/4 genotypes exhibited similar patterns of change in total cholesterol and LDL-C from ages 8 to 18, while individuals with the ε2/3 genotype demonstrated a significantly different pattern of change (age2 x genotype interaction, P < .05). For example, individuals with the ε2/3 genotype showed a slight increase in total cholesterol from approximately 141 to 146 mg/dL from ages 8 to 10; total cholesterol then decreased monotonically from ages 10 to 18 from 146 to 115 mg/dL. The apo E effect on total cholesterol and LDL-C and their change during adolescence is strong and may be modified by factors affecting growth, maturation, and reproductive function.
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U2 - 10.1016/S0026-0495(99)90073-2
DO - 10.1016/S0026-0495(99)90073-2
M3 - Article
C2 - 10094101
AN - SCOPUS:0032968654
SN - 0026-0495
VL - 48
SP - 285
EP - 290
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 3
ER -
