Apolipoprotein e levels in the cerebrospinal fluid of north Indian patients with Alzheimer's disease

Ramesh J.L. Kandimalla, Willayat Yousuf Wani, R. Anand, Alka Kaushal, Sudesh Prabhakar, Vinod K. Grover, Neerja Bharadwaj, Kajal Jain, Kiran Dip Gill*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The etiology of Alzheimer's disease (AD) is multifactorial involving both genetic and environmental factors. Apolipoprotein E (ApoE) gene plays a pivotal role in risk and age of onset of AD. Although it is broadly accepted that ApoE genotype is linked to the pathogenesis of AD, there are still controversial results regarding the association of ApoE levels in cerebrospinal fluid (CSF) with the occurrence of AD. Some studies have shown a positive correlation between CSF ApoE levels and AD, whereas others showed no link. In this study, we measured ApoE levels to assess the usefulness of CSF ApoE as a diagnostic marker of AD by comparing the levels in 3 patient groups and in control participants. No significant difference was observed in CSF ApoE concentrations between the patients with AD and the controls. So, it appears that CSF ApoE measurement does not offer any diagnostic advantage for AD.

Original languageEnglish (US)
Pages (from-to)258-262
Number of pages5
JournalAmerican Journal of Alzheimer's Disease and Other Dementias
Issue number3
StatePublished - May 2013


  • Alzheimer's disease
  • ApoE
  • cerebrospinal fluid
  • Indian population

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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