Apoptosis in rheumatoid arthritis: Friend or foe

Hongtao Liu, Richard M. Pope*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

A better understanding of the mechanisms that contribute to the resistance of synovial macrophages and fibroblasts to apoptosis will not only provide better insights into the mechanisms contributing to the perpetuation of rheumatoid arthritis (RA) but will also help identify targets for the development of novel, more effective, and long-lasting therapies for the treatment of patients with RA. To avoid toxicity, such as the induction of apoptosis of critical organs, the mechanisms by which these molecules are targeted and therapy delivered must be carefully selected, using the insights obtained from studies characterizing the mechanisms that promote chronic inflammation.

Original languageEnglish (US)
Pages (from-to)603-625
Number of pages23
JournalRheumatic Disease Clinics of North America
Volume30
Issue number3
DOIs
StatePublished - Aug 2004

ASJC Scopus subject areas

  • Rheumatology

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