Apoptosis-independent functions of killer caspases

Alicia Algeciras-Schimnich; Bryan C. Barnhart; Marcus E. Peter

doi:10.1016/S0955-0674(02)00384-8

Apoptosis-independent functions of killer caspases

Alicia Algeciras-Schimnich^*, Bryan C. Barnhart, Marcus E. Peter

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Review article › peer-review

103 Scopus citations

Abstract

Caspases are well known for their role in the execution of the apoptotic program by cleaving specific target proteins, leading to the dismantling of the cell, as well as for mediating cytokine maturation. Recent work has highlighted novel non-apoptotic activities of apoptotic caspases. These reports indicate that caspases are much more versatile enzymes than we originally expected. In addition to regulating cell survival and cytokine maturation, caspases may be involved in regulating cell differentiation, cell proliferation, spreading and receptor internalization.

Original language	English (US)
Pages (from-to)	721-726
Number of pages	6
Journal	Current Opinion in Cell Biology
Volume	14
Issue number	6
DOIs	https://doi.org/10.1016/S0955-0674(02)00384-8
State	Published - Dec 1 2002

Funding

Support to ME Peter has been provided by National Institutes of Health grant GM61712. A Algeciras-Schimnich is supported by the Cancer Biology Training Program 5T32CA09594. BC Barnhart is supported by the Molecular and Cell Biology training grant 5T32GM07183.

ASJC Scopus subject areas

Cell Biology

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10.1016/S0955-0674(02)00384-8

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title = "Apoptosis-independent functions of killer caspases",

abstract = "Caspases are well known for their role in the execution of the apoptotic program by cleaving specific target proteins, leading to the dismantling of the cell, as well as for mediating cytokine maturation. Recent work has highlighted novel non-apoptotic activities of apoptotic caspases. These reports indicate that caspases are much more versatile enzymes than we originally expected. In addition to regulating cell survival and cytokine maturation, caspases may be involved in regulating cell differentiation, cell proliferation, spreading and receptor internalization.",

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AU - Algeciras-Schimnich, Alicia

AU - Barnhart, Bryan C.

AU - Peter, Marcus E.

N1 - Funding Information: Support to ME Peter has been provided by National Institutes of Health grant GM61712. A Algeciras-Schimnich is supported by the Cancer Biology Training Program 5T32CA09594. BC Barnhart is supported by the Molecular and Cell Biology training grant 5T32GM07183. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Caspases are well known for their role in the execution of the apoptotic program by cleaving specific target proteins, leading to the dismantling of the cell, as well as for mediating cytokine maturation. Recent work has highlighted novel non-apoptotic activities of apoptotic caspases. These reports indicate that caspases are much more versatile enzymes than we originally expected. In addition to regulating cell survival and cytokine maturation, caspases may be involved in regulating cell differentiation, cell proliferation, spreading and receptor internalization.

AB - Caspases are well known for their role in the execution of the apoptotic program by cleaving specific target proteins, leading to the dismantling of the cell, as well as for mediating cytokine maturation. Recent work has highlighted novel non-apoptotic activities of apoptotic caspases. These reports indicate that caspases are much more versatile enzymes than we originally expected. In addition to regulating cell survival and cytokine maturation, caspases may be involved in regulating cell differentiation, cell proliferation, spreading and receptor internalization.

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Apoptosis-independent functions of killer caspases

Abstract

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ASJC Scopus subject areas

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