TY - JOUR
T1 - Apoptosis-independent functions of killer caspases
AU - Algeciras-Schimnich, Alicia
AU - Barnhart, Bryan C.
AU - Peter, Marcus E.
N1 - Funding Information:
Support to ME Peter has been provided by National Institutes of Health grant GM61712. A Algeciras-Schimnich is supported by the Cancer Biology Training Program 5T32CA09594. BC Barnhart is supported by the Molecular and Cell Biology training grant 5T32GM07183.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2002/12/1
Y1 - 2002/12/1
N2 - Caspases are well known for their role in the execution of the apoptotic program by cleaving specific target proteins, leading to the dismantling of the cell, as well as for mediating cytokine maturation. Recent work has highlighted novel non-apoptotic activities of apoptotic caspases. These reports indicate that caspases are much more versatile enzymes than we originally expected. In addition to regulating cell survival and cytokine maturation, caspases may be involved in regulating cell differentiation, cell proliferation, spreading and receptor internalization.
AB - Caspases are well known for their role in the execution of the apoptotic program by cleaving specific target proteins, leading to the dismantling of the cell, as well as for mediating cytokine maturation. Recent work has highlighted novel non-apoptotic activities of apoptotic caspases. These reports indicate that caspases are much more versatile enzymes than we originally expected. In addition to regulating cell survival and cytokine maturation, caspases may be involved in regulating cell differentiation, cell proliferation, spreading and receptor internalization.
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U2 - 10.1016/S0955-0674(02)00384-8
DO - 10.1016/S0955-0674(02)00384-8
M3 - Review article
C2 - 12473345
AN - SCOPUS:0036900130
VL - 14
SP - 721
EP - 726
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
IS - 6
ER -