Apoptosis-independent functions of killer caspases

Alicia Algeciras-Schimnich*, Bryan C. Barnhart, Marcus E. Peter

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

102 Scopus citations


Caspases are well known for their role in the execution of the apoptotic program by cleaving specific target proteins, leading to the dismantling of the cell, as well as for mediating cytokine maturation. Recent work has highlighted novel non-apoptotic activities of apoptotic caspases. These reports indicate that caspases are much more versatile enzymes than we originally expected. In addition to regulating cell survival and cytokine maturation, caspases may be involved in regulating cell differentiation, cell proliferation, spreading and receptor internalization.

Original languageEnglish (US)
Pages (from-to)721-726
Number of pages6
JournalCurrent Opinion in Cell Biology
Issue number6
StatePublished - Dec 1 2002

ASJC Scopus subject areas

  • Cell Biology


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