Apoptoz kletok L929 pod deistviem faktora nekroza opukholei.

A. B. Moshnikova; K. E. Krotova; V. V. Galat; V. N. Afanas'ev; V. B. Sadovnikov; I. P. Beletskiǐ

Apoptoz kletok L929 pod deistviem faktora nekroza opukholei.

Translated title of the contribution: Apoptosis of L929 cells induced by tumor necrosis factor

A. B. Moshnikova^*, K. E. Krotova, V. V. Galat, V. N. Afanas'ev, V. B. Sadovnikov, I. P. Beletskiǐ

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the mode of TNF-dependent death of L929 murine fibroblasts and the influence of overexpression of bcl-2 family genes on this process. Based on morphological and biochemical data it has been shown that L929 cells died after TNF treatment by apoptosis irrespective of TNF dose and protein synthesis inhibition. Analysis of bcl-2 family gene transfectants revealed a down-regulation of TNF-induced apoptosis by bcl-2 and bclX overexpression, and an up-regulation by bax gene.

Translated title of the contribution	Apoptosis of L929 cells induced by tumor necrosis factor
Original language	Russian
Pages (from-to)	561-567
Number of pages	7
Journal	Tsitologiya
Volume	42
Issue number	6
State	Published - Oct 12 2000

ASJC Scopus subject areas

General Medicine

Cite this

@article{805a00c41e134d47b3eb6f1f564f914e,

title = "Apoptoz kletok L929 pod deistviem faktora nekroza opukholei.",

abstract = "We investigated the mode of TNF-dependent death of L929 murine fibroblasts and the influence of overexpression of bcl-2 family genes on this process. Based on morphological and biochemical data it has been shown that L929 cells died after TNF treatment by apoptosis irrespective of TNF dose and protein synthesis inhibition. Analysis of bcl-2 family gene transfectants revealed a down-regulation of TNF-induced apoptosis by bcl-2 and bclX overexpression, and an up-regulation by bax gene.",

author = "Moshnikova, {A. B.} and Krotova, {K. E.} and Galat, {V. V.} and Afanas'ev, {V. N.} and Sadovnikov, {V. B.} and Beletskiǐ, {I. P.}",

year = "2000",

month = oct,

day = "12",

language = "Russian",

volume = "42",

pages = "561--567",

journal = "Tsitologiya",

issn = "0041-3771",

publisher = "Maik Nauka-Interperiodica Publishing",

number = "6",

}

TY - JOUR

T1 - Apoptoz kletok L929 pod deistviem faktora nekroza opukholei.

AU - Moshnikova, A. B.

AU - Krotova, K. E.

AU - Galat, V. V.

AU - Afanas'ev, V. N.

AU - Sadovnikov, V. B.

AU - Beletskiǐ, I. P.

PY - 2000/10/12

Y1 - 2000/10/12

N2 - We investigated the mode of TNF-dependent death of L929 murine fibroblasts and the influence of overexpression of bcl-2 family genes on this process. Based on morphological and biochemical data it has been shown that L929 cells died after TNF treatment by apoptosis irrespective of TNF dose and protein synthesis inhibition. Analysis of bcl-2 family gene transfectants revealed a down-regulation of TNF-induced apoptosis by bcl-2 and bclX overexpression, and an up-regulation by bax gene.

AB - We investigated the mode of TNF-dependent death of L929 murine fibroblasts and the influence of overexpression of bcl-2 family genes on this process. Based on morphological and biochemical data it has been shown that L929 cells died after TNF treatment by apoptosis irrespective of TNF dose and protein synthesis inhibition. Analysis of bcl-2 family gene transfectants revealed a down-regulation of TNF-induced apoptosis by bcl-2 and bclX overexpression, and an up-regulation by bax gene.

UR - http://www.scopus.com/inward/record.url?scp=0033648475&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033648475&partnerID=8YFLogxK

M3 - Article

C2 - 10953861

SN - 0041-3771

VL - 42

SP - 561

EP - 567

JO - Tsitologiya

JF - Tsitologiya

IS - 6

ER -

Apoptoz kletok L929 pod deistviem faktora nekroza opukholei.

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this