Apoptoz kletok L929 pod deistviem faktora nekroza opukholei.

Translated title of the contribution: Apoptosis of L929 cells induced by tumor necrosis factor

A. B. Moshnikova*, K. E. Krotova, V. V. Galat, V. N. Afanas'ev, V. B. Sadovnikov, I. P. Beletskiǐ

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We investigated the mode of TNF-dependent death of L929 murine fibroblasts and the influence of overexpression of bcl-2 family genes on this process. Based on morphological and biochemical data it has been shown that L929 cells died after TNF treatment by apoptosis irrespective of TNF dose and protein synthesis inhibition. Analysis of bcl-2 family gene transfectants revealed a down-regulation of TNF-induced apoptosis by bcl-2 and bclX overexpression, and an up-regulation by bax gene.

Translated title of the contributionApoptosis of L929 cells induced by tumor necrosis factor
Original languageRussian
Pages (from-to)561-567
Number of pages7
Issue number6
StatePublished - Oct 12 2000

ASJC Scopus subject areas

  • Medicine(all)


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