Apoptotic regulators and RA

Jack Hutcheson; Harris R Perlman

doi:10.2174/157339708786263870

Apoptotic regulators and RA

Jack Hutcheson, Harris R Perlman^*

^*Corresponding author for this work

Medicine, Rheumatology Division

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Although the etiology of rheumatoid arthritis (RA) is currently unknown, the disease is mediated by chronic inflammation within the joint, characterized by leukocyte recruitment and the presence of pro-inflammatory cytokines such as TNFα, IL-1, IL-8, and MCP-1. In this review, we discuss recent studies suggesting that apoptosis plays an important role in preventing the development of RA by reducing the number of leukocytes in the joint. These studies provide the groundwork for a potentially new therapeutic approach towards RA.

Original language	English (US)
Pages (from-to)	254-258
Number of pages	5
Journal	Current Rheumatology Reviews
Volume	4
Issue number	4
DOIs	https://doi.org/10.2174/157339708786263870
State	Published - 2008

Keywords

Apoptosis
BH3-proteins
Leukocytes
Pro-inflammatory cytokines
Rheumatoid arthritis

ASJC Scopus subject areas

Rheumatology

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10.2174/157339708786263870

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title = "Apoptotic regulators and RA",

abstract = "Although the etiology of rheumatoid arthritis (RA) is currently unknown, the disease is mediated by chronic inflammation within the joint, characterized by leukocyte recruitment and the presence of pro-inflammatory cytokines such as TNFα, IL-1, IL-8, and MCP-1. In this review, we discuss recent studies suggesting that apoptosis plays an important role in preventing the development of RA by reducing the number of leukocytes in the joint. These studies provide the groundwork for a potentially new therapeutic approach towards RA.",

keywords = "Apoptosis, BH3-proteins, Leukocytes, Pro-inflammatory cytokines, Rheumatoid arthritis",

author = "Jack Hutcheson and Perlman, {Harris R}",

note = "Funding Information: This project was supported by Pre-doctoral fellowship from an American Heart Association grant to Dr. JackHutcheson (0710060Z) and from the National Institutes of Health (AR02147, AR050250) to Dr. Harris Perlman. The authors indicate that they have no conflicting financial interests. Publisher Copyright: {\textcopyright} 2008 Bentham Science Publishers Ltd.",

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AU - Hutcheson, Jack

AU - Perlman, Harris R

N1 - Funding Information: This project was supported by Pre-doctoral fellowship from an American Heart Association grant to Dr. JackHutcheson (0710060Z) and from the National Institutes of Health (AR02147, AR050250) to Dr. Harris Perlman. The authors indicate that they have no conflicting financial interests. Publisher Copyright: © 2008 Bentham Science Publishers Ltd.

PY - 2008

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N2 - Although the etiology of rheumatoid arthritis (RA) is currently unknown, the disease is mediated by chronic inflammation within the joint, characterized by leukocyte recruitment and the presence of pro-inflammatory cytokines such as TNFα, IL-1, IL-8, and MCP-1. In this review, we discuss recent studies suggesting that apoptosis plays an important role in preventing the development of RA by reducing the number of leukocytes in the joint. These studies provide the groundwork for a potentially new therapeutic approach towards RA.

AB - Although the etiology of rheumatoid arthritis (RA) is currently unknown, the disease is mediated by chronic inflammation within the joint, characterized by leukocyte recruitment and the presence of pro-inflammatory cytokines such as TNFα, IL-1, IL-8, and MCP-1. In this review, we discuss recent studies suggesting that apoptosis plays an important role in preventing the development of RA by reducing the number of leukocytes in the joint. These studies provide the groundwork for a potentially new therapeutic approach towards RA.

KW - Apoptosis

KW - BH3-proteins

KW - Leukocytes

KW - Pro-inflammatory cytokines

KW - Rheumatoid arthritis

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Apoptotic regulators and RA

Abstract

Keywords

ASJC Scopus subject areas

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