Aporphines 15 action of aporphine alkaloids on dopaminergic mechanisms in rat brain

Richard J. Miller*, Peter H. Kelly, John L. Neumeyer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Of eleven aporphine analogues tested on striatal adenylate cyclase only (-)-apomorphine and (±)-N-n-propyl-norapomorphine (±-(NPA)) were effective in stimulating the cyclase from rat brain. Inactive compounds included (±)-isoapomorphine, (-)-1,2-dihydroxyaporphine and (±)-10-hydroxy-N-n-propylnoraporphine. (+)-Bulbocapnine was an effective antagonist of the stimulating effects of dopamine or (-)-apomorphine on striatal adenylate cyclase. Injection of (-)-apomorphine into the lateral ventricle of rats with unilateral 6-hdyroxydopamine-induced lesions of the nigro-striatal pathway caused the animals to rotate away from the side of the lesion. Intraventricular injection of 25 μ (±)-10-hydroxy-N-n-propylnorapomorphine was ineffective in producing rotation. The results are discussed in relation to the structural requirements for CNS dopamine receptor agonists.

Original languageEnglish (US)
Pages (from-to)77-83
Number of pages7
JournalEuropean Journal of Pharmacology
Volume35
Issue number1
DOIs
StatePublished - Jan 1976

Keywords

  • (+)-Bulbocapnine
  • Apomorphine
  • Aporphines
  • Cyclic AMP
  • Dopamine
  • Rotational behaviour

ASJC Scopus subject areas

  • Pharmacology

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