Aporphines 16 Action of aporphine alkaloids on locomotor activity in rats with 6-hydroxydopamine lesions of the nucleus accumbens

Peter H. Kelly*, Richard J. Miller, John L. Neumeyer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

(-)-Apomorphine and (±)-N-n-propylnorapomorphine ((±)-NPA) produce stereotypy but not locomotor activity in normal rats. In rats with selective bilateral lesions of dopamine terminals in the nucleus accumbens induced by microinjection of 6-hydroxydopamine both compounds produced a marked stimulation of locomotor activity (±)-NPA was considerably more potent than (-)-apomorphine. The maximal intensity of stimulation produced by the two drugs was, however, similar. The locomotor stimulant effects of (-)-apomorphine were inhibited by (+)-bulbocapnine (20 mg/kg) or pimozide (0.5 mg/kg). (±)-N-n-Propylnorapocodeine also produced a long-lasting stimulation of locomotor activity. (±)-Aporphine, (±)-isoapomorphine, (-)-1,2-dihydroxyaporphine, and (-)-nuciferine were all inactive in stimulating locomotor activity.

Original languageEnglish (US)
Pages (from-to)85-92
Number of pages8
JournalEuropean Journal of Pharmacology
Volume35
Issue number1
DOIs
StatePublished - Jan 1 1976

Keywords

  • Apomorphine
  • Aporphines
  • Denervation supersensitivity
  • Dopamine antagonists
  • Dopamine receptor
  • Locomotor stimulation
  • Nucleus accumbens

ASJC Scopus subject areas

  • Pharmacology

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