Abstract
An application of finite-element analysis with an optimisation technique to assess the myocardial material properties in diastasis in vivo is described. Using the data collected from an animal model, the three-dimensional geometry of the left ventricular chamber, at several times in diastole, was reconstructed. From the measurement of the ventricular chamber pressure during image acquisition, finite-element analysis was performed to predict the expansion during diastasis. Initially, by restricting the motion of the epicardial nodes and computing the reaction forces, an 'equivalent pericardial pressure' was determined and applied in subsequent analysis. The duration of diastasis was divided into three or four intervals and the analysis was performed at each interval to assess the material properties of the myocardium. Using such a step-wise linear approach, the non-linear material properties of the myocardium during passive expansion was determined. Our results demonstrated that the computed 'equivalent pericardial pressure' increased with and was smaller than the corresponding left ventricularchamber pressure. The passive myocardium exhibited a linear tangent modulus against chamber pressure relationship which is equivalent to an exponential stress/strain relationship, similar to those suggested by in vitro studies.
Original language | English (US) |
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Pages (from-to) | 459-467 |
Number of pages | 9 |
Journal | Medical & Biological Engineering & Computing |
Volume | 31 |
Issue number | 5 |
DOIs | |
State | Published - Sep 1993 |
Funding
Keywords
- Exponential stress/strain relationship
- Finite-element analysis
- Left ventricular expansion
- Passive myocardium
- Tangential elastic modulus
- Three-dimensional geometry
ASJC Scopus subject areas
- Biomedical Engineering
- Computer Science Applications