Background: By complete reading of the genome sequence, in the near future we will be able to determine the role of genomic DNA sequence variation among individuals, such a single nucleotide polymorphism (SNP), in the pathogenesis of diseases and responses to drugs. Comprehension of the genome will also accelerate understanding of the transcriptome, the whole transcripts present in a cell. Messages induced by a new therapy, such as an unexpected adverse effect, will not be missed by using such a comprehensive assay. Allergic diseases will be classified into subtypes depending on the impaired or affected molecule. Methods/Data base: We introduce our research strategy for genome-wide analysis of SNP related to asthma, granted by the Millennium Genome Project of the Japanese Government, and review the recent results of transcriptome analysis using microarray technology. Results/Conclusion: In the very near future, the probability of asthma, as well as that of other allergic diseases, will be examined in every hospital by screening all SNP and transcriptome information related to the diseases. However, until now, even the most risky SNP combination related to asthma has only a twofold odds ratio with controls and most SNP research papers deal only with statistical probability. Many problems remain to be resolved before the clinical application of genomic information regarding asthma and other allergic diseases.
ASJC Scopus subject areas
- Immunology and Allergy