TY - JOUR
T1 - Application of measurement error models to correct for systematic differences among readers and vendors in echocardiography measurements
T2 - the CARDIA study
AU - Betoko, Aisha
AU - Nwabuo, Chike
AU - Ambale Venkatesh, Bharath
AU - Ricketts, Erin P.
AU - Bae, Sejong
AU - Wu, Colin
AU - Gidding, Samuel S.
AU - Liu, Kiang
AU - Lima, João A.C.
AU - Cox, Christopher
N1 - Funding Information:
The Coronary Artery Risk Development in Young Adults Study (CARDIA) is supported by contracts HHSN268201800003I, HHSN268201800004I, HHSN268201800005I, HHSN268201800006I, and HHSN268201800007I from the National Heart, Lung, and Blood Institute (NHLBI). The authors would like to thank four reviewers and the Associate Editor for their detailed and constructive comments.
Publisher Copyright:
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2020/5/18
Y1 - 2020/5/18
N2 - We illustrate the application of linear measurement error models to calibrate echocardiography measurements acquired 20 years apart in the CARDIA study. Of 4242 echocardiograms acquired at Year-5 (1990–1991), 36% were reread 20 years later. Left ventricular (LV) mass and 8 other measurements were assessed. A machine reproducibility study including 96 additional patients also compared Year-5 and Year-25 equipment. A linear measurement error model was developed to calibrate the original Year-5 measurements, incorporating the additional Year-5 reread and machine reproducibility study data, and adjusting for differences among readers and machines. Median (quartiles) of original Year-5 LV mass was 144.4 (117.6, 174.2) g before and 129.9 (103.8, 158.6) g, after calibration. The correlation between original and calibrated LV mass was 0.989 (95% confidence interval: 0.988, 0.990). The original and calibrated measurements had similar distributions. Additional comparisons of original and calibrated data supported the use of the model. We conclude that systematic differences among readers and machines have been accounted for, and that the calibrated Year-5 measurements can be used in future longitudinal comparisons. It is hoped that this paper will encourage the wider application of measurement error models.
AB - We illustrate the application of linear measurement error models to calibrate echocardiography measurements acquired 20 years apart in the CARDIA study. Of 4242 echocardiograms acquired at Year-5 (1990–1991), 36% were reread 20 years later. Left ventricular (LV) mass and 8 other measurements were assessed. A machine reproducibility study including 96 additional patients also compared Year-5 and Year-25 equipment. A linear measurement error model was developed to calibrate the original Year-5 measurements, incorporating the additional Year-5 reread and machine reproducibility study data, and adjusting for differences among readers and machines. Median (quartiles) of original Year-5 LV mass was 144.4 (117.6, 174.2) g before and 129.9 (103.8, 158.6) g, after calibration. The correlation between original and calibrated LV mass was 0.989 (95% confidence interval: 0.988, 0.990). The original and calibrated measurements had similar distributions. Additional comparisons of original and calibrated data supported the use of the model. We conclude that systematic differences among readers and machines have been accounted for, and that the calibrated Year-5 measurements can be used in future longitudinal comparisons. It is hoped that this paper will encourage the wider application of measurement error models.
KW - Bias
KW - calibration
KW - echocardiography
KW - linear measurement error models
KW - systematic differences
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U2 - 10.1080/02664763.2019.1686133
DO - 10.1080/02664763.2019.1686133
M3 - Article
C2 - 35707021
AN - SCOPUS:85075215412
VL - 47
SP - 1315
EP - 1324
JO - Journal of Applied Statistics
JF - Journal of Applied Statistics
SN - 0266-4763
IS - 7
ER -