Application of the F-Response for Estimating Motor Unit Number and Amplitude Distribution in Hand Muscles of Stroke Survivors

Xiaoyan Li, Morris Fisher, William Zev Rymer, Ping Zhou

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The F-response was used in this study to assess changes in the first dorsal interosseous (FDI) muscle after a hemispheric stroke. The number of motor units and their sizes were estimated bilaterally in 12 stroke survivors by recording both the compound muscle action potential (CMAP) and F wave responses. These F waves were induced by applying a large number of electrical stimuli to the ulnar nerve. The amplitude distribution of individual motor unit action potentials (MUAPs) was also compared between paretic and contralateral muscles. When averaged across all the subjects, a significantly lower motor unit number estimate was obtained for the paretic FDI muscle (88 ± 13) compared with the contralateral side (139 ± 11) (p < 0.01). Pooled surface MUAP amplitude analysis demonstrated a right-skewed distribution for both paretic (kurtosis 3.0) and contralateral (kurtosis 8.52) muscles. When normalized to each individual muscle's CMAP, the surface MUAP amplitude ranged from 0.22% to 4.94% (median 1.17%) of CMAP amplitude for the paretic muscle, and from 0.13% to 3.2% (median 0.62%) of CMAP amplitude for the contralateral muscle. A significant difference in MUAP outliers was also observed between the paretic and contralateral muscles. The findings of this study suggest significant motor unit loss and muscle structural reorganization after stroke.

Original languageEnglish (US)
Article number7152933
Pages (from-to)674-681
Number of pages8
JournalIEEE Transactions on Neural Systems and Rehabilitation Engineering
Volume24
Issue number6
DOIs
StatePublished - Jun 2016

Keywords

  • F wave
  • hemiparetic stroke
  • motor unit action potential (MUAP)
  • motor unit number estimation (MUNE)
  • surface electromyogram (EMG)

ASJC Scopus subject areas

  • Internal Medicine
  • Neuroscience(all)
  • Biomedical Engineering

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