Applications of arterial spin labeled MRI in the brain

John A. Detre*, Hengyi Rao, Danny J.J. Wang, Yu Fen Chen, Ze Wang

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

179 Scopus citations

Abstract

Perfusion provides oxygen and nutrients to tissues and is closely tied to tissue function while disorders of perfusion are major sources of medical morbidity and mortality. It has been almost two decades since the use of arterial spin labeling (ASL) for noninvasive perfusion imaging was first reported. While initial ASL magnetic resonance imaging (MRI) studies focused primarily on technological development and validation, a number of robust ASL implementations have emerged, and ASL MRI is now also available commercially on several platforms. As a result, basic science and clinical applications of ASL MRI have begun to proliferate. Although ASL MRI can be carried out in any organ, most studies to date have focused on the brain. This review covers selected research and clinical applications of ASL MRI in the brain to illustrate its potential in both neuroscience research and clinical care.

Original languageEnglish (US)
Pages (from-to)1026-1037
Number of pages12
JournalJournal of Magnetic Resonance Imaging
Volume35
Issue number5
DOIs
StatePublished - May 2012

Keywords

  • Arterial spin labeling
  • Brain function
  • Cerebral blood flow
  • Clinical neuroscience
  • Cognitive neuroscience
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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