Applications of optical resonance to biological imaging and label-free protein microarrays.

M. Selim Unlü*, I. E. Ozkumur, J. Needham, D. A. Bergstein, B. B. Goldberg, A. Yalcin, P. Spuhler, R. Irani, C. DeLisi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We present biological imaging and sensing methods based on optical resonance and interference. In fluorescence microscopy, our nanoscale imaging capability sheds light onto conformational changes of DNA, DNA-protein complexes and polymer coatings on a solid surface. Interference measurements on a layered substrate yield a label-free sensing platform for protein binding in a high-throughput micro-array format.

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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