Approach to Intestinal Failure in Children

Danielle Wendel*, Conrad R. Cole, Valeria C. Cohran

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Purpose of Review: Pediatric intestinal failure is a complex condition requiring specialized care to prevent potential complications. In this article, we review the available evidence supporting recent advances in care for children with intestinal failure. Recent Findings: Multidisciplinary intestinal rehabilitation teams utilize medical and surgical management techniques to help patients achieve enteral autonomy (EA) while preventing and treating the complications associated with intestinal failure. Recent advances in lipid management strategies, minimization of intestinal failure associated liver disease, prevention of central line-associated blood stream infections, and loss of access, as well as development of promising new hormone analogue therapy have allowed promotion of intestinal adaptation. These advances have decreased the need for intestinal transplant. Summary: There have been recent advances in the care of children with intestinal failure decreasing morbidity, mortality, and need for intestinal transplantation. The most promising new therapies involve replacement of enteroendocrine hormones.

Original languageEnglish (US)
Article number8
JournalCurrent gastroenterology reports
Issue number6
StatePublished - Jun 2021


  • Central venous access
  • Intestinal failure associated liver disease
  • Intestinal rehabilitation
  • Intestinal transplant
  • Parenteral nutrition
  • Teduglutide

ASJC Scopus subject areas

  • Gastroenterology


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