Approach to Optimizing Growth, Rehabilitation, and Neurodevelopmental Outcomes in Children After Solid-organ Transplantation

Saeed Mohammad*, Estella M Alonso

*Corresponding author for this work

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

One of the most critical differences between the posttransplant care of children and adults is the requirement in children to maintain a state of health that supports normal physical and psychological growth and development. Most children with organ failure have some degree of growth failure and developmental delay, which is not quickly reversed after successful transplantation. The challenge for clinicians caring for these children is to use strategies that minimize these deficits before transplantation and provide maximal opportunity for recovery of normal developmental processes during posttransplant rehabilitation. The effect of chronic organ failure, frequently complicated by malnutrition, on growth potential and cognitive development is poorly understood. This review presents a summary of what is known regarding risk factors for suboptimal growth and development following solid-organ transplant and describe possible strategies to improve these outcomes.

Original languageEnglish (US)
Pages (from-to)539-557
Number of pages19
JournalPediatric Clinics of North America
Volume57
Issue number2
DOIs
StatePublished - Apr 1 2010

Fingerprint

Organ Transplantation
Growth and Development
Growth
Transplantation
Child Care
Malnutrition
Rehabilitation
Psychology
Transplants
Health

Keywords

  • Cognitive function
  • Growth
  • Heart transplantation
  • Intestinal transplantation
  • Kidney transplantation
  • Liver transplantation
  • Quality of life

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

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N2 - One of the most critical differences between the posttransplant care of children and adults is the requirement in children to maintain a state of health that supports normal physical and psychological growth and development. Most children with organ failure have some degree of growth failure and developmental delay, which is not quickly reversed after successful transplantation. The challenge for clinicians caring for these children is to use strategies that minimize these deficits before transplantation and provide maximal opportunity for recovery of normal developmental processes during posttransplant rehabilitation. The effect of chronic organ failure, frequently complicated by malnutrition, on growth potential and cognitive development is poorly understood. This review presents a summary of what is known regarding risk factors for suboptimal growth and development following solid-organ transplant and describe possible strategies to improve these outcomes.

AB - One of the most critical differences between the posttransplant care of children and adults is the requirement in children to maintain a state of health that supports normal physical and psychological growth and development. Most children with organ failure have some degree of growth failure and developmental delay, which is not quickly reversed after successful transplantation. The challenge for clinicians caring for these children is to use strategies that minimize these deficits before transplantation and provide maximal opportunity for recovery of normal developmental processes during posttransplant rehabilitation. The effect of chronic organ failure, frequently complicated by malnutrition, on growth potential and cognitive development is poorly understood. This review presents a summary of what is known regarding risk factors for suboptimal growth and development following solid-organ transplant and describe possible strategies to improve these outcomes.

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KW - Growth

KW - Heart transplantation

KW - Intestinal transplantation

KW - Kidney transplantation

KW - Liver transplantation

KW - Quality of life

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