Approaches to Biopsy and Resection Specimens from the Ampulla

Yue Xue, Michelle D. Reid*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


The ampulla of Vater gives rise to a versatile group of cancers of mixed/hybrid histologic phenotype. Ampullary carcinomas (ACs) are most frequently intestinal or pancreatobiliary adenocarcinomas but other subtypes, such as medullary, mucinous, or signet ring/poorly cohesive cell carcinoma, may be encountered. Ampullary cancer can also be subclassified based on immunohistochemical features, however these classification systems fail to show robust prognostic reliability. More recently, the molecular landscape of AC has been uncovered, and has been shown to have prognostic and predictive significance. In this article, the site-specific, histologic, and genetic characteristics of ampullary carcinoma and its precursor lesions are discussed.

Original languageEnglish (US)
Pages (from-to)453-467
Number of pages15
JournalSurgical Pathology Clinics
Issue number3
StatePublished - Sep 2020


  • Ampulla
  • Ampullary
  • Ampullary carcinoma
  • Duodenal adenoma
  • IAPN
  • Intra-ampullary papillary-tubular neoplasm

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine


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