Abstract
Abstract: The United States (U.S.) National Institutes of Health–funded Environmental influences on Child Health Outcomes (ECHO)-wide Cohort was established to conduct high impact, transdisciplinary science to improve child health and development. The cohort is a collaborative research design in which both extant and new data are contributed by over 57,000 children across 69 cohorts. In this review article, we focus on two key challenging issues in the ECHO-wide Cohort: data collection standardization and data harmonization. Data standardization using a Common Data Model and derived analytical variables based on a team science approach should facilitate timely analyses and reduce errors due to data misuse. However, given the complexity of collaborative research designs, such as the ECHO-wide Cohort, dedicated time is needed for harmonization and derivation of analytic variables. These activities need to be done methodically and with transparency to enhance research reproducibility. Impact: Many collaborative research studies require data harmonization either prior to analyses or in the analyses of compiled data. The Environmental influences on Child Health Outcomes (ECHO) Cohort pools extant data with new data collection from over 57,000 children in 69 cohorts to conduct high-impact, transdisciplinary science to improve child health and development, and to provide a national database and biorepository for use by the scientific community at-large. We describe the tools, systems, and approaches we employed to facilitate harmonized data for impactful analyses of child health outcomes.
Original language | English (US) |
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Pages (from-to) | 1726-1733 |
Number of pages | 8 |
Journal | Pediatric research |
Volume | 95 |
Issue number | 7 |
DOIs | |
State | Published - Jun 2024 |
Funding
ECHO research is supported by the Environmental influences on Child Health Outcomes (ECHO) Program, Office of The Director, NIH, under Award Numbers U2COD023375 (Coordinating Center), U24OD023382 (DAC), U24 OD03319 (PRO Core); Cohort awards: UH3 OD023244; UH3 OD023248; UH3 OD023249; UH3 OD023251; UH3 OD023253; UH3 OD023268; UH3 OD023271; UH3 OD023272; UH3 OD023275; UH3 OD023279; UH3 OD023282; UH3 OD023285; UH3 OD023286; UH3 OD023287; UH3 OD023288; UH3 OD023289; UH3 OD023290; UH3 OD023305; UH3 OD023313; UH3 OD023318; UH3 OD023320; UH3 OD023328; UH3 OD023332; UH3 OD023337; UH3 OD023342; UH3 OD023344; UH3 OD023347; UH3 OD023348; UH3 OD023349; UH3 OD023365; UH3 OD023389; Laboratories: U24 ES026539. U2C ES026533; U2C ES026542; U2C ES030859; U2C ES030857; U2C ES026555; U2C ES026561; U2C ES030851; U2C OD023375; IDeA States Pediatric Clinical Trial Network: U24 OD024957-02; UG1 OD024943-02; UG1 OD024945-02; UG1 OD024947-02; UG1 OD024954-02; UG1 OD024958-02; UG1 OD024952-02; UG1 OD024956-02; UG1 OD024946-02; UG1 OD024951-02; UG1 OD024959-02; UG1 OD024948-02; UG1 OD024950-02; UG1 OD024953-02; UG1 OD024955-02; UG1 OD024942-02; UG1 OD024944-02; and UG1 OD024949-02. L.P.J. and C.B.P. were supported by U24 OD023382, D.C. was supported by U24 OD023319, B.M.L. was supported by UH3 OD023347, and D.K.M. was supported by U24 OD023319, R01-AG067622, R01-AG064006 and P30AG059988. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health