Approaches to the Modelling of the Hydrodynamic Properties of Rigid Biomacromolecules: Some Quantitative Comparisons

Matthew Tirrell, John Torkelson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Quantitative comparisons are made between calculations based on the best currently available predictive theories and experiments on the motions of rigid biomacromolecules and complexes through fluid media. Hydrodynamic properties calculated are translational diffusion coefficient, sedimentation coefficient, intrinsic viscosity, and rotational relaxation time. Structures for which calculations have been done are those representative of urease, polystyrene latex spheres with adsorbed 7-globulin, aspartate transcarbamylase, and once-broken rods. Conclusions are that sensitivity to structure in the hydrodynamic properties has the following order: first normal stress coefficient, 1 rotational relaxation time, r intrinsic viscosity, [tj] translational diffusion coefficient, Dr R= sedimentation coefficient, Shs„,; and that a model proposed by Abdel-Khalik and Bird has good predictive capability except for structures which must be modelled by large numbers of subunits.

Original languageEnglish (US)
Pages (from-to)751-768
Number of pages18
JournalJournal of Rheology
Volume23
Issue number6
DOIs
StatePublished - Dec 1979

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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