Approaches to transfusion therapy and iron overload in patients with sickle cell disease: Results of an international survey

Elliott P. Vichinsky; Kwaku Ohene-Frempong; Swee Lay Thein; Clarisse Lopes De Castro Lobo; Adlette Inati; Alexis A. Thompson; Kim Smith-Whitley; Janet L. Kwiatkowski; Paul S. Swerdlow; John B. Porter; Peter W. Marks

doi:10.3109/08880018.2010.505497

Approaches to transfusion therapy and iron overload in patients with sickle cell disease: Results of an international survey

Elliott P. Vichinsky, Kwaku Ohene-Frempong, Swee Lay Thein, Clarisse Lopes De Castro Lobo, Adlette Inati, Alexis A. Thompson, Kim Smith-Whitley, Janet L. Kwiatkowski, Paul S. Swerdlow, John B. Porter, Peter W. Marks

Pediatrics

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

To gain an insight into current transfusion and chelation practice in patients with sickle cell disease (SCD), a survey of international experts has been conducted. The findings demonstrate that general utilization of transfusion therapy is low, the primary barrier to treatment being concerns over resultant iron overload and the subsequent need for iron chelation therapy. Where patients were transfused, many physicians indicated that a high proportion of patients had hemosiderosis. As evidence suggests more patients with SCD could benefit from regular transfusion therapy, it is apparent that greater awareness of the need to monitor and treat iron overload in transfused patients is required.

Original language	English (US)
Pages (from-to)	37-42
Number of pages	6
Journal	Pediatric Hematology and Oncology
Volume	28
Issue number	1
DOIs	https://doi.org/10.3109/08880018.2010.505497
State	Published - Feb 2011

Keywords

iron overload
sickle cell disease
transfusion therapy

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.3109/08880018.2010.505497

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Vichinsky, E. P., Ohene-Frempong, K., Thein, S. L., Lobo, C. L. D. C., Inati, A., Thompson, A. A., Smith-Whitley, K., Kwiatkowski, J. L., Swerdlow, P. S., Porter, J. B., & Marks, P. W. (2011). Approaches to transfusion therapy and iron overload in patients with sickle cell disease: Results of an international survey. Pediatric Hematology and Oncology, 28(1), 37-42. https://doi.org/10.3109/08880018.2010.505497

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title = "Approaches to transfusion therapy and iron overload in patients with sickle cell disease: Results of an international survey",

abstract = "To gain an insight into current transfusion and chelation practice in patients with sickle cell disease (SCD), a survey of international experts has been conducted. The findings demonstrate that general utilization of transfusion therapy is low, the primary barrier to treatment being concerns over resultant iron overload and the subsequent need for iron chelation therapy. Where patients were transfused, many physicians indicated that a high proportion of patients had hemosiderosis. As evidence suggests more patients with SCD could benefit from regular transfusion therapy, it is apparent that greater awareness of the need to monitor and treat iron overload in transfused patients is required.",

keywords = "iron overload, sickle cell disease, transfusion therapy",

author = "Vichinsky, {Elliott P.} and Kwaku Ohene-Frempong and Thein, {Swee Lay} and Lobo, {Clarisse Lopes De Castro} and Adlette Inati and Thompson, {Alexis A.} and Kim Smith-Whitley and Kwiatkowski, {Janet L.} and Swerdlow, {Paul S.} and Porter, {John B.} and Marks, {Peter W.}",

note = "Funding Information: Received and accepted September 2006. The SCD global experts and regional advisory board meeting in Sept. 2006, and delegate attendance, were supported by Novartis Pharmaceuticals Corporation. Financial support for medical editorial assistance was provided by Novartis Pharmaceuticals. The authors thank Ruth Tidey, PhD, for medical editorial assistance with the manuscript. Address correspondence to Elliott Vichinsky, MD, Medical Director Hematology/Oncology Department, Children{\textquoteright}s Hospital & Research Center Oakland, 747 52nd Street, Oakland, CA 94609, USA. E-mail: EVichinsky@mail.cho.org",

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doi = "10.3109/08880018.2010.505497",

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Vichinsky, EP, Ohene-Frempong, K, Thein, SL, Lobo, CLDC, Inati, A, Thompson, AA, Smith-Whitley, K, Kwiatkowski, JL, Swerdlow, PS, Porter, JB & Marks, PW 2011, 'Approaches to transfusion therapy and iron overload in patients with sickle cell disease: Results of an international survey', Pediatric Hematology and Oncology, vol. 28, no. 1, pp. 37-42. https://doi.org/10.3109/08880018.2010.505497

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AU - Vichinsky, Elliott P.

AU - Ohene-Frempong, Kwaku

AU - Thein, Swee Lay

AU - Lobo, Clarisse Lopes De Castro

AU - Inati, Adlette

AU - Thompson, Alexis A.

AU - Smith-Whitley, Kim

AU - Kwiatkowski, Janet L.

AU - Swerdlow, Paul S.

AU - Porter, John B.

AU - Marks, Peter W.

N1 - Funding Information: Received and accepted September 2006. The SCD global experts and regional advisory board meeting in Sept. 2006, and delegate attendance, were supported by Novartis Pharmaceuticals Corporation. Financial support for medical editorial assistance was provided by Novartis Pharmaceuticals. The authors thank Ruth Tidey, PhD, for medical editorial assistance with the manuscript. Address correspondence to Elliott Vichinsky, MD, Medical Director Hematology/Oncology Department, Children’s Hospital & Research Center Oakland, 747 52nd Street, Oakland, CA 94609, USA. E-mail: EVichinsky@mail.cho.org

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Approaches to transfusion therapy and iron overload in patients with sickle cell disease: Results of an international survey

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Keywords

ASJC Scopus subject areas

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