Approaches to transfusion therapy and iron overload in patients with sickle cell disease: Results of an international survey

Elliott P. Vichinsky, Kwaku Ohene-Frempong, Swee Lay Thein, Clarisse Lopes De Castro Lobo, Adlette Inati, Alexis A. Thompson, Kim Smith-Whitley, Janet L. Kwiatkowski, Paul S. Swerdlow, John B. Porter, Peter W. Marks

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

To gain an insight into current transfusion and chelation practice in patients with sickle cell disease (SCD), a survey of international experts has been conducted. The findings demonstrate that general utilization of transfusion therapy is low, the primary barrier to treatment being concerns over resultant iron overload and the subsequent need for iron chelation therapy. Where patients were transfused, many physicians indicated that a high proportion of patients had hemosiderosis. As evidence suggests more patients with SCD could benefit from regular transfusion therapy, it is apparent that greater awareness of the need to monitor and treat iron overload in transfused patients is required.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalPediatric Hematology and Oncology
Volume28
Issue number1
DOIs
StatePublished - Feb 2011

Keywords

  • iron overload
  • sickle cell disease
  • transfusion therapy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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