Aptamer-based viability impedimetric sensor for viruses

Mahmoud Labib, Anna S. Zamay, Darija Muharemagic, Alexey V. Chechik, John C. Bell, Maxim V. Berezovski*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


The development of aptamer-based viability impedimetric sensor for viruses (AptaVISens-V) is presented. Highly specific DNA aptamers to intact vaccinia virus were selected using cell-SELEX technique and integrated into impedimetric sensors via self-assembly onto a gold microelectrode. Remarkably, this aptasensor is highly selective and can successfully detect viable vaccinia virus particles (down to 60 virions in a microliter) and distinguish them from nonviable viruses in a label-free electrochemical assay format. It also opens a new venue for the development of a variety of viability sensors for detection of many microorganisms and spores.

Original languageEnglish (US)
Pages (from-to)1813-1816
Number of pages4
JournalAnalytical Chemistry
Issue number4
StatePublished - Feb 21 2012
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry


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