Aquaporin-2 as a biomarker of distal renal tubular function using lithium as an experimental model

David Sisson, Daniel Batlle*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Aquaporin-2 protein levels can be detected in the urine of normal of subjects if measured after fluid deprivation. By contrast, in patients with nephrogenic diabetes insipidus caused by mutations in the aquaporin-2 gene, urine aquaporin-2 protein excretion cannot be detected. We propose that properly standardized measurements of urinary aquaporin-2 protein may provide a useful biomarker of distal tubular function in a variety of acquired conditions that impair concentrating ability including some nephrotoxic agents.

Original languageEnglish (US)
Pages (from-to)331-336
Number of pages6
JournalRenal Failure
Volume21
Issue number3-4
DOIs
StatePublished - Jan 1 1999

Keywords

  • Aquaporin-2
  • Lithium
  • Nephrogenic diabetes insipidus

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nephrology

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