Aqueous Self-Assembly of Unsymmetric Peptide Bolaamphiphiles into Nanofibers with Hydrophilic Cores and Surfaces

Randal C. Claussen, Bryan M. Rabatic, Samuel I. Stupp*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

178 Scopus citations

Abstract

Unsymmetric peptide bolaamphiphiles that incorporate (L-glutamyl)3glycine at one terminus and either tetraethylene glycol or aspartic acid at the other were found to form hydrogels at low wt %, presumably by self-assembling into nanofibers presenting (L-glutamyl)3glycine at their surfaces and burying the second headgroup at their cores. Transmission electron microscopy measurements on 1 wt % gels negatively stained with phosphotungstic acid and positively stained with uranyl acetate show one-dimensional objects with diameters of 5 nm and lengths in excess of 1 μm. Circular dichroism and solid-state FTIR spectra indicate the adoption of β-sheet structure within the nanofibers.

Original languageEnglish (US)
Pages (from-to)12680-12681
Number of pages2
JournalJournal of the American Chemical Society
Volume125
Issue number42
DOIs
StatePublished - Oct 22 2003

ASJC Scopus subject areas

  • General Chemistry
  • Biochemistry
  • Catalysis
  • Colloid and Surface Chemistry

Fingerprint

Dive into the research topics of 'Aqueous Self-Assembly of Unsymmetric Peptide Bolaamphiphiles into Nanofibers with Hydrophilic Cores and Surfaces'. Together they form a unique fingerprint.

Cite this