Abstract
Unsymmetric peptide bolaamphiphiles that incorporate (L-glutamyl)3glycine at one terminus and either tetraethylene glycol or aspartic acid at the other were found to form hydrogels at low wt %, presumably by self-assembling into nanofibers presenting (L-glutamyl)3glycine at their surfaces and burying the second headgroup at their cores. Transmission electron microscopy measurements on 1 wt % gels negatively stained with phosphotungstic acid and positively stained with uranyl acetate show one-dimensional objects with diameters of 5 nm and lengths in excess of 1 μm. Circular dichroism and solid-state FTIR spectra indicate the adoption of β-sheet structure within the nanofibers.
Original language | English (US) |
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Pages (from-to) | 12680-12681 |
Number of pages | 2 |
Journal | Journal of the American Chemical Society |
Volume | 125 |
Issue number | 42 |
DOIs | |
State | Published - Oct 22 2003 |
ASJC Scopus subject areas
- General Chemistry
- Biochemistry
- Catalysis
- Colloid and Surface Chemistry