Architectural design of the pelvic floor is consistent with muscle functional subspecialization

Lori J. Tuttle, Olivia T. Nguyen, Mark S. Cook, Marianna Alperin, Sameer B. Shah, Samuel R. Ward, Richard L. Lieber*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Introduction and hypothesis: Skeletal muscle architecture is the strongest predictor of a muscle's functional capacity. The purpose of this study was to define the architectural properties of the deep muscles of the female pelvic floor (PFMs) to elucidate their structure-function relationships. Methods: PFMs coccygeus (C), iliococcygeus (IC), and pubovisceral (PV) were harvested en bloc from ten fixed human cadavers (mean age 85 years, range 55-102). Fundamental architectural parameters of skeletal muscles [physiological cross-sectional area (PCSA), normalized fiber length, and sarcomere length (Ls)] were determined using validated methods. PCSA predicts muscle-force production, and normalized fiber length is related to muscle excursion. These parameters were compared using repeated measures analysis of variance (ANOVA) with post hoc t tests, as appropriate. Significance was set to α = 0.05. Results: PFMs were thinner than expected based on data reported from imaging studies and in vivo palpation. Significant differences in fiber length were observed across PFMs: C=5.29±0.32 cm, IC=7.55±0.46 cm, PV=10.45±0.67 cm (p <0.001). Average Ls of all PFMs was short relative to the optimal Ls of 2.7 μm of other human skeletal muscles: C=2.05±0.02 μm, IC=2.02±0.02 μm, PC/PR=2.07±0.01 μm (p =<0.001 compared with 2.7 μm; p =0.15 between PFMs, power=0.46). Average PCSA was very small compared with other human muscles, with no significant difference between individual PFMs: C=0.71±0.06 cm2, IC=0.63±0.04 cm2, PV=0.59±0.05 cm2 (p =0.21, power=0.27). Overall, C had shortest fibers, making it a good stabilizer. PV demonstrated the longest fibers, suggesting that it functions to produce large excursions. Conclusions: PFM design shows individual muscles demonstrating differential architecture, corresponding to specialized function in the pelvic floor.

Original languageEnglish (US)
Pages (from-to)205-212
Number of pages8
JournalInternational urogynecology journal and pelvic floor dysfunction
Volume25
Issue number2
DOIs
StatePublished - Feb 2014

Keywords

  • Muscle architecture
  • Muscle function
  • Pelvic floor

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Urology

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