Architecture of fluid intelligence and working memory revealed by lesion mapping

Aron K. Barbey; Roberto Colom; Erick J. Paul; Jordan Grafman

doi:10.1007/s00429-013-0512-z

Architecture of fluid intelligence and working memory revealed by lesion mapping

Aron K. Barbey^*, Roberto Colom, Erick J. Paul, Jordan Grafman

^*Corresponding author for this work

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

Although cognitive neuroscience has made valuable progress in understanding the role of the prefrontal cortex in human intelligence, the functional networks that support adaptive behavior and novel problem solving remain to be well characterized. Here, we studied 158 human brain lesion patients to investigate the cognitive and neural foundations of key competencies for fluid intelligence and working memory. We administered a battery of neuropsychological tests, including the Wechsler Adult Intelligence Scale (WAIS) and the N-Back task. Latent variable modeling was applied to obtain error-free scores of fluid intelligence and working memory, followed by voxel-based lesion-symptom mapping to elucidate their neural substrates. The observed latent variable modeling and lesion results support an integrative framework for understanding the architecture of fluid intelligence and working memory and make specific recommendations for the interpretation and application of the WAIS and N-Back task to the study of fluid intelligence in health and disease.

Original language	English (US)
Pages (from-to)	485-494
Number of pages	10
Journal	Brain Structure and Function
Volume	219
Issue number	2
DOIs	https://doi.org/10.1007/s00429-013-0512-z
State	Published - Mar 2014

Funding

We are grateful to S. Bonifant, B. Cheon, C. Ngo, A. Greathouse, V. Raymont, K. Reding, and G. Tasick for their invaluable help with the testing of participants and organization of this study. This work was supported by funding from the US National Institute of Neurological Disorders and Stroke intramural research program and a project grant from the United States Army Medical Research and Material Command administered by the Henry M. Jackson Foundation (Vietnam Head Injury Study Phase III: a 30-year post-injury follow-up study, grant number DAMD17-01-1-0675). R. Colom was supported by grant PSI2010-20364 from Ministerio de Ciencia e Innovación [Ministry of Science and Innovation, Spain].

Keywords

Fluid intelligence
Prefrontal cortex
Voxel-based lesion-symptom mapping
Working memory

ASJC Scopus subject areas

Anatomy
General Neuroscience
Histology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Architecture of fluid intelligence and working memory revealed by lesion mapping",

abstract = "Although cognitive neuroscience has made valuable progress in understanding the role of the prefrontal cortex in human intelligence, the functional networks that support adaptive behavior and novel problem solving remain to be well characterized. Here, we studied 158 human brain lesion patients to investigate the cognitive and neural foundations of key competencies for fluid intelligence and working memory. We administered a battery of neuropsychological tests, including the Wechsler Adult Intelligence Scale (WAIS) and the N-Back task. Latent variable modeling was applied to obtain error-free scores of fluid intelligence and working memory, followed by voxel-based lesion-symptom mapping to elucidate their neural substrates. The observed latent variable modeling and lesion results support an integrative framework for understanding the architecture of fluid intelligence and working memory and make specific recommendations for the interpretation and application of the WAIS and N-Back task to the study of fluid intelligence in health and disease.",

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author = "Barbey, {Aron K.} and Roberto Colom and Paul, {Erick J.} and Jordan Grafman",

note = "Funding Information: We are grateful to S. Bonifant, B. Cheon, C. Ngo, A. Greathouse, V. Raymont, K. Reding, and G. Tasick for their invaluable help with the testing of participants and organization of this study. This work was supported by funding from the US National Institute of Neurological Disorders and Stroke intramural research program and a project grant from the United States Army Medical Research and Material Command administered by the Henry M. Jackson Foundation (Vietnam Head Injury Study Phase III: a 30-year post-injury follow-up study, grant number DAMD17-01-1-0675). R. Colom was supported by grant PSI2010-20364 from Ministerio de Ciencia e Innovaci{\'o}n [Ministry of Science and Innovation, Spain].",

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Architecture of fluid intelligence and working memory revealed by lesion mapping

Abstract

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Keywords

ASJC Scopus subject areas

UN SDGs

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