Are desmosomes more than tethers for intermediate filaments?

Kathleen J. Green*, Claire A. Gaudry

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

307 Scopus citations

Abstract

Desmosomes are intercellular adhesive junctions that anchor intermediate filaments at membrane-associated plaques in adjoining cells, thereby forming a three-dimensional supracellular scaffolding that provides tissues with mechanical strength. But desmosomes have also recently been recognized as sensors that respond to environmental and cellular cues by modulating their assembly state and, possibly, their signalling functions.

Original languageEnglish (US)
Pages (from-to)208-216
Number of pages9
JournalNature Reviews Molecular Cell Biology
Volume1
Issue number3
DOIs
StatePublished - Dec 2000

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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