TY - JOUR
T1 - Are there consistent abnormalities in event-related EEG oscillations in patients with Alzheimer’s disease compared to other diseases belonging to dementia?
AU - Güntekin, Bahar
AU - Aktürk, Tuba
AU - Arakaki, Xianghong
AU - Bonanni, Laura
AU - Del Percio, Claudio
AU - Edelmayer, Rebecca
AU - Farina, Francesca
AU - Ferri, Raffaele
AU - Hanoğlu, Lütfü
AU - Kumar, Sanjeev
AU - Lizio, Roberta
AU - Lopez, Susanna
AU - Murphy, Brian
AU - Noce, Giuseppe
AU - Randall, Fiona
AU - Sack, Alexander T.
AU - Stocchi, Fabrizio
AU - Yener, Görsev
AU - Yıldırım, Ebru
AU - Babiloni, Claudio
N1 - Funding Information:
Dr. Claudio Babiloni is supported by European Committee (H2020‐EU.1.3.1.H2020‐MSCA‐ITN‐ETN‐2016 project with short title “BBDiag”)
Funding Information:
Dr. Claudio Babiloni is supported by European Committee (H2020-EU.1.3.1.H2020-MSCA-ITN-ETN-2016 project with short title ?BBDiag?) This manuscript was facilitated by the Alzheimer?s Association International Society to Advance Alzheimer?s Research and Treatment (ISTAART), through the Electrophysiology Professional Interest Area (PIA). The views and opinions expressed by the authors in this publication represent those of the authors and do not necessarily reflect those of the PIA membership, ISTAART or the Alzheimer?s Association. The EPIA is committed to exploiting biomarkers for (1) improving the understanding of neurophysiological mechanisms underlying Alzheimer?s disease and other dementias at micro, meso, and macro spatial scales and (2) promoting clinical applications and international initiatives. EPIA members believe that quantitative EEG techniques and biomarkers are an important resource for brain research and clinical applications in neurologic and psychiatric diseases, especially in lower- and middle-income countries.
Publisher Copyright:
© 2021 Society for Psychophysiological Research.
PY - 2022/5
Y1 - 2022/5
N2 - Cerebrospinal and structural-molecular neuroimaging in-vivo biomarkers are recommended for diagnostic purposes in Alzheimer’s disease (AD) and other dementias; however, they do not explain the effects of AD neuropathology on neurophysiological mechanisms underpinning cognitive processes. Here, an Expert Panel from the Electrophysiology Professional Interest Area of the Alzheimer’s Association reviewed the field literature and reached consensus on the event-related electroencephalographic oscillations (EROs) that show consistent abnormalities in patients with significant cognitive deficits due to Alzheimer’s, Parkinson’s (PD), Lewy body (LBD), and cerebrovascular diseases. Converging evidence from oddball paradigms showed that, as compared to cognitively unimpaired (CU) older adults, AD patients had lower amplitude in widespread delta (>4 Hz) and theta (4–7 Hz) phase-locked EROs as a function of disease severity. Similar effects were also observed in PD, LBD, and/or cerebrovascular cognitive impairment patients. Non-phase-locked alpha (8–12 Hz) and beta (13–30 Hz) oscillations were abnormally reduced (event-related desynchronization, ERD) in AD patients relative to CU. However, studies on patients with other dementias remain lacking. Delta and theta phase-locked EROs during oddball tasks may be useful neurophysiological biomarkers of cognitive systems at work in heuristic and intervention clinical trials performed in AD patients, but more research is needed regarding their potential role for other dementias.
AB - Cerebrospinal and structural-molecular neuroimaging in-vivo biomarkers are recommended for diagnostic purposes in Alzheimer’s disease (AD) and other dementias; however, they do not explain the effects of AD neuropathology on neurophysiological mechanisms underpinning cognitive processes. Here, an Expert Panel from the Electrophysiology Professional Interest Area of the Alzheimer’s Association reviewed the field literature and reached consensus on the event-related electroencephalographic oscillations (EROs) that show consistent abnormalities in patients with significant cognitive deficits due to Alzheimer’s, Parkinson’s (PD), Lewy body (LBD), and cerebrovascular diseases. Converging evidence from oddball paradigms showed that, as compared to cognitively unimpaired (CU) older adults, AD patients had lower amplitude in widespread delta (>4 Hz) and theta (4–7 Hz) phase-locked EROs as a function of disease severity. Similar effects were also observed in PD, LBD, and/or cerebrovascular cognitive impairment patients. Non-phase-locked alpha (8–12 Hz) and beta (13–30 Hz) oscillations were abnormally reduced (event-related desynchronization, ERD) in AD patients relative to CU. However, studies on patients with other dementias remain lacking. Delta and theta phase-locked EROs during oddball tasks may be useful neurophysiological biomarkers of cognitive systems at work in heuristic and intervention clinical trials performed in AD patients, but more research is needed regarding their potential role for other dementias.
KW - Alzheimer’s disease (AD)
KW - Alzheimer’s disease mild cognitive impairment (ADMCI)
KW - event-related desynchronization
KW - event-related oscillations (EROs)
KW - event-related potentials (ERPs)
KW - event-related synchronization
KW - lewy body dementia (LBD)
KW - Parkinson’s disease (PD)
KW - vascular cognitive impairment (VCI)
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U2 - 10.1111/psyp.13934
DO - 10.1111/psyp.13934
M3 - Article
C2 - 34460957
AN - SCOPUS:85113871269
SN - 0048-5772
VL - 59
JO - Psychophysiology
JF - Psychophysiology
IS - 5
M1 - e13934
ER -