Abstract
Cerebrospinal and structural-molecular neuroimaging in-vivo biomarkers are recommended for diagnostic purposes in Alzheimer’s disease (AD) and other dementias; however, they do not explain the effects of AD neuropathology on neurophysiological mechanisms underpinning cognitive processes. Here, an Expert Panel from the Electrophysiology Professional Interest Area of the Alzheimer’s Association reviewed the field literature and reached consensus on the event-related electroencephalographic oscillations (EROs) that show consistent abnormalities in patients with significant cognitive deficits due to Alzheimer’s, Parkinson’s (PD), Lewy body (LBD), and cerebrovascular diseases. Converging evidence from oddball paradigms showed that, as compared to cognitively unimpaired (CU) older adults, AD patients had lower amplitude in widespread delta (>4 Hz) and theta (4–7 Hz) phase-locked EROs as a function of disease severity. Similar effects were also observed in PD, LBD, and/or cerebrovascular cognitive impairment patients. Non-phase-locked alpha (8–12 Hz) and beta (13–30 Hz) oscillations were abnormally reduced (event-related desynchronization, ERD) in AD patients relative to CU. However, studies on patients with other dementias remain lacking. Delta and theta phase-locked EROs during oddball tasks may be useful neurophysiological biomarkers of cognitive systems at work in heuristic and intervention clinical trials performed in AD patients, but more research is needed regarding their potential role for other dementias.
| Original language | English (US) |
|---|---|
| Article number | e13934 |
| Journal | Psychophysiology |
| Volume | 59 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2022 |
Funding
Dr. Claudio Babiloni is supported by European Committee (H2020‐EU.1.3.1.H2020‐MSCA‐ITN‐ETN‐2016 project with short title “BBDiag”) Dr. Claudio Babiloni is supported by European Committee (H2020-EU.1.3.1.H2020-MSCA-ITN-ETN-2016 project with short title ?BBDiag?) This manuscript was facilitated by the Alzheimer?s Association International Society to Advance Alzheimer?s Research and Treatment (ISTAART), through the Electrophysiology Professional Interest Area (PIA). The views and opinions expressed by the authors in this publication represent those of the authors and do not necessarily reflect those of the PIA membership, ISTAART or the Alzheimer?s Association. The EPIA is committed to exploiting biomarkers for (1) improving the understanding of neurophysiological mechanisms underlying Alzheimer?s disease and other dementias at micro, meso, and macro spatial scales and (2) promoting clinical applications and international initiatives. EPIA members believe that quantitative EEG techniques and biomarkers are an important resource for brain research and clinical applications in neurologic and psychiatric diseases, especially in lower- and middle-income countries.
Keywords
- Alzheimer’s disease (AD)
- Alzheimer’s disease mild cognitive impairment (ADMCI)
- event-related desynchronization
- event-related oscillations (EROs)
- event-related potentials (ERPs)
- event-related synchronization
- lewy body dementia (LBD)
- Parkinson’s disease (PD)
- vascular cognitive impairment (VCI)
ASJC Scopus subject areas
- General Neuroscience
- Neuropsychology and Physiological Psychology
- Experimental and Cognitive Psychology
- Neurology
- Endocrine and Autonomic Systems
- Developmental Neuroscience
- Cognitive Neuroscience
- Biological Psychiatry