Areas of brain damage underlying increased reports of behavioral disinhibition

Kristine M. Knutson, Olga Dal Monte, Selene Schintu, Eric M. Wassermann, Vanessa Raymont, Jordan Grafman, Frank Krueger*

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Disinhibition, the inability to inhibit inappropriate behavior, is seen in frontal-temporal degeneration, Alzheimer’s disease, and stroke. Behavioral disinhibition leads to social and emotional impairments, including impulsive behavior and disregard for social conventions. The authors investigated the effects of lesions on behavioral disinhibition measured by the Neuropsychiatric Inventory in 177 veterans with traumatic brain injuries. The authors performed voxel-based lesion-symptom mapping using MEDx. Damage in the frontal and temporal lobes, gyrus rectus, and insula was associated with greater behavioral disinhibition, providing further evidence of the frontal lobe’s involvement in behavioral inhibition and suggesting that these regions are necessary to inhibit improper behavior.

Original languageEnglish (US)
Pages (from-to)193-198
Number of pages6
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume27
Issue number3
DOIs
StatePublished - Aug 26 2015

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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