Areas of brain damage underlying increased reports of behavioral disinhibition

Kristine M. Knutson, Olga Dal Monte, Selene Schintu, Eric M. Wassermann, Vanessa Raymont, Jordan Henry Grafman, Frank Krueger*

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Disinhibition, the inability to inhibit inappropriate behavior, is seen in frontal-temporal degeneration, Alzheimer’s disease, and stroke. Behavioral disinhibition leads to social and emotional impairments, including impulsive behavior and disregard for social conventions. The authors investigated the effects of lesions on behavioral disinhibition measured by the Neuropsychiatric Inventory in 177 veterans with traumatic brain injuries. The authors performed voxel-based lesion-symptom mapping using MEDx. Damage in the frontal and temporal lobes, gyrus rectus, and insula was associated with greater behavioral disinhibition, providing further evidence of the frontal lobe’s involvement in behavioral inhibition and suggesting that these regions are necessary to inhibit improper behavior.

Original languageEnglish (US)
Pages (from-to)193-198
Number of pages6
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume27
Issue number3
DOIs
StatePublished - Aug 26 2015

Fingerprint

Frontal Lobe
Temporal Lobe
Impulsive Behavior
Brain
Veterans
Prefrontal Cortex
Alzheimer Disease
Stroke
Equipment and Supplies
Inhibition (Psychology)
Traumatic Brain Injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Knutson, Kristine M. ; Dal Monte, Olga ; Schintu, Selene ; Wassermann, Eric M. ; Raymont, Vanessa ; Grafman, Jordan Henry ; Krueger, Frank. / Areas of brain damage underlying increased reports of behavioral disinhibition. In: Journal of Neuropsychiatry and Clinical Neurosciences. 2015 ; Vol. 27, No. 3. pp. 193-198.
@article{91a7057ca7874fb08c35c269710cdaef,
title = "Areas of brain damage underlying increased reports of behavioral disinhibition",
abstract = "Disinhibition, the inability to inhibit inappropriate behavior, is seen in frontal-temporal degeneration, Alzheimer’s disease, and stroke. Behavioral disinhibition leads to social and emotional impairments, including impulsive behavior and disregard for social conventions. The authors investigated the effects of lesions on behavioral disinhibition measured by the Neuropsychiatric Inventory in 177 veterans with traumatic brain injuries. The authors performed voxel-based lesion-symptom mapping using MEDx. Damage in the frontal and temporal lobes, gyrus rectus, and insula was associated with greater behavioral disinhibition, providing further evidence of the frontal lobe’s involvement in behavioral inhibition and suggesting that these regions are necessary to inhibit improper behavior.",
author = "Knutson, {Kristine M.} and {Dal Monte}, Olga and Selene Schintu and Wassermann, {Eric M.} and Vanessa Raymont and Grafman, {Jordan Henry} and Frank Krueger",
year = "2015",
month = "8",
day = "26",
doi = "10.1176/appi.neuropsych.14060126",
language = "English (US)",
volume = "27",
pages = "193--198",
journal = "Journal of Neuropsychiatry and Clinical Neurosciences",
issn = "0895-0172",
publisher = "American Psychiatric Publishing Inc.",
number = "3",

}

Areas of brain damage underlying increased reports of behavioral disinhibition. / Knutson, Kristine M.; Dal Monte, Olga; Schintu, Selene; Wassermann, Eric M.; Raymont, Vanessa; Grafman, Jordan Henry; Krueger, Frank.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 27, No. 3, 26.08.2015, p. 193-198.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Areas of brain damage underlying increased reports of behavioral disinhibition

AU - Knutson, Kristine M.

AU - Dal Monte, Olga

AU - Schintu, Selene

AU - Wassermann, Eric M.

AU - Raymont, Vanessa

AU - Grafman, Jordan Henry

AU - Krueger, Frank

PY - 2015/8/26

Y1 - 2015/8/26

N2 - Disinhibition, the inability to inhibit inappropriate behavior, is seen in frontal-temporal degeneration, Alzheimer’s disease, and stroke. Behavioral disinhibition leads to social and emotional impairments, including impulsive behavior and disregard for social conventions. The authors investigated the effects of lesions on behavioral disinhibition measured by the Neuropsychiatric Inventory in 177 veterans with traumatic brain injuries. The authors performed voxel-based lesion-symptom mapping using MEDx. Damage in the frontal and temporal lobes, gyrus rectus, and insula was associated with greater behavioral disinhibition, providing further evidence of the frontal lobe’s involvement in behavioral inhibition and suggesting that these regions are necessary to inhibit improper behavior.

AB - Disinhibition, the inability to inhibit inappropriate behavior, is seen in frontal-temporal degeneration, Alzheimer’s disease, and stroke. Behavioral disinhibition leads to social and emotional impairments, including impulsive behavior and disregard for social conventions. The authors investigated the effects of lesions on behavioral disinhibition measured by the Neuropsychiatric Inventory in 177 veterans with traumatic brain injuries. The authors performed voxel-based lesion-symptom mapping using MEDx. Damage in the frontal and temporal lobes, gyrus rectus, and insula was associated with greater behavioral disinhibition, providing further evidence of the frontal lobe’s involvement in behavioral inhibition and suggesting that these regions are necessary to inhibit improper behavior.

UR - http://www.scopus.com/inward/record.url?scp=84940030607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940030607&partnerID=8YFLogxK

U2 - 10.1176/appi.neuropsych.14060126

DO - 10.1176/appi.neuropsych.14060126

M3 - Article

C2 - 25959040

AN - SCOPUS:84940030607

VL - 27

SP - 193

EP - 198

JO - Journal of Neuropsychiatry and Clinical Neurosciences

JF - Journal of Neuropsychiatry and Clinical Neurosciences

SN - 0895-0172

IS - 3

ER -