Aromatase in endometriosis and uterine leiomyomata

Serdar E. Bulun; Gonca Imir; Hiroki Utsunomiya; Steven Thung; Bilgin Gurates; Mitsutoshi Tamura; Zhihong Lin

doi:10.1016/j.jsbmb.2005.04.012

Aromatase in endometriosis and uterine leiomyomata

Serdar E. Bulun^*, Gonca Imir, Hiroki Utsunomiya, Steven Thung, Bilgin Gurates, Mitsutoshi Tamura, Zhihong Lin

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

138 Scopus citations

Abstract

Endometrial tissue from uterine disease-free women does not exhibit aromatase activity. In contrast, aromatase enzyme activity and mRNA levels are readily detectable in endometriosis. PGE₂ stimulates both aromatase expression and activity in endometriotic stromal cells via promoter II region of the aromatase gene. This results in local production of estradiol, which induces PGE₂ formation and establishes a positive feedback cycle. This mechanism seems to contribute to continuous production of estradiol and PGE₂. Aromatase mRNA levels and enzyme activity are also present in uterine leiomyomata that are estrogen-dependent benign tumors of the myometrium. Successful treatment of endometriosis and uterine leiomyomata using aromatase inhibitors by recent pilot trials underscores the clinical significance of these molecular studies.

Original language	English (US)
Pages (from-to)	57-62
Number of pages	6
Journal	Journal of Steroid Biochemistry and Molecular Biology
Volume	95
Issue number	1-5
DOIs	https://doi.org/10.1016/j.jsbmb.2005.04.012
State	Published - May 2005

Funding

This research work was supported, in part, by the grants HD38691 and HD46260 from the NICHD and a grant from the Friends of Prentice (to Serdar Bulun).

Keywords

Anastrozole
Aromatase
Aromatase inhibitor
Endometriosis
Endometrium
Estrogen
Estrogen biosynthesis
Letrozole
Uterine leiomyomata
Uterus

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Medicine
Molecular Biology
Endocrinology
Clinical Biochemistry
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jsbmb.2005.04.012

Cite this

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title = "Aromatase in endometriosis and uterine leiomyomata",

abstract = "Endometrial tissue from uterine disease-free women does not exhibit aromatase activity. In contrast, aromatase enzyme activity and mRNA levels are readily detectable in endometriosis. PGE2 stimulates both aromatase expression and activity in endometriotic stromal cells via promoter II region of the aromatase gene. This results in local production of estradiol, which induces PGE2 formation and establishes a positive feedback cycle. This mechanism seems to contribute to continuous production of estradiol and PGE2. Aromatase mRNA levels and enzyme activity are also present in uterine leiomyomata that are estrogen-dependent benign tumors of the myometrium. Successful treatment of endometriosis and uterine leiomyomata using aromatase inhibitors by recent pilot trials underscores the clinical significance of these molecular studies.",

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author = "Bulun, {Serdar E.} and Gonca Imir and Hiroki Utsunomiya and Steven Thung and Bilgin Gurates and Mitsutoshi Tamura and Zhihong Lin",

note = "Funding Information: This research work was supported, in part, by the grants HD38691 and HD46260 from the NICHD and a grant from the Friends of Prentice (to Serdar Bulun).",

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doi = "10.1016/j.jsbmb.2005.04.012",

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AU - Bulun, Serdar E.

AU - Imir, Gonca

AU - Utsunomiya, Hiroki

AU - Thung, Steven

AU - Gurates, Bilgin

AU - Tamura, Mitsutoshi

AU - Lin, Zhihong

N1 - Funding Information: This research work was supported, in part, by the grants HD38691 and HD46260 from the NICHD and a grant from the Friends of Prentice (to Serdar Bulun).

PY - 2005/5

Y1 - 2005/5

N2 - Endometrial tissue from uterine disease-free women does not exhibit aromatase activity. In contrast, aromatase enzyme activity and mRNA levels are readily detectable in endometriosis. PGE2 stimulates both aromatase expression and activity in endometriotic stromal cells via promoter II region of the aromatase gene. This results in local production of estradiol, which induces PGE2 formation and establishes a positive feedback cycle. This mechanism seems to contribute to continuous production of estradiol and PGE2. Aromatase mRNA levels and enzyme activity are also present in uterine leiomyomata that are estrogen-dependent benign tumors of the myometrium. Successful treatment of endometriosis and uterine leiomyomata using aromatase inhibitors by recent pilot trials underscores the clinical significance of these molecular studies.

AB - Endometrial tissue from uterine disease-free women does not exhibit aromatase activity. In contrast, aromatase enzyme activity and mRNA levels are readily detectable in endometriosis. PGE2 stimulates both aromatase expression and activity in endometriotic stromal cells via promoter II region of the aromatase gene. This results in local production of estradiol, which induces PGE2 formation and establishes a positive feedback cycle. This mechanism seems to contribute to continuous production of estradiol and PGE2. Aromatase mRNA levels and enzyme activity are also present in uterine leiomyomata that are estrogen-dependent benign tumors of the myometrium. Successful treatment of endometriosis and uterine leiomyomata using aromatase inhibitors by recent pilot trials underscores the clinical significance of these molecular studies.

KW - Anastrozole

KW - Aromatase

KW - Aromatase inhibitor

KW - Endometriosis

KW - Endometrium

KW - Estrogen

KW - Estrogen biosynthesis

KW - Letrozole

KW - Uterine leiomyomata

KW - Uterus

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ER -

Aromatase in endometriosis and uterine leiomyomata

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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