Aromatase inhibitors for the treatment of endometriosis

Mary Ellen Pavone*, Serdar E. Bulun

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

86 Scopus citations


Objective: To review the use of aromatase inhibitors (AIs) for the treatment of endometriosis. Design: Literature review. Conclusion(s): Most studies show that in reproductive-age women, the combination of AI with conventional therapy alleviates endometriosis-related pain. In postmenopausal women, using an AI alone has been shown to be an effective treatment, although more studies are needed in this subgroup. Side effects of using AIs appear to be tolerable in most women, although special consideration should be given to monitoring bone mineral density. More studies need to be done examining pregnancy rates and outcomes after AI treatment for endometriosis. In addition, larger randomized clinical trials using AIs need to be done. In summary, AIs may be effective in treating endometriosis-related chronic pelvic pain in both reproductive-age and postmenopausal women.

Original languageEnglish (US)
Pages (from-to)1370-1379
Number of pages10
JournalFertility and Sterility
Issue number6
StatePublished - Dec 2012


  • Endometriosis
  • GnRH agonist
  • anastrozole
  • aromatase inhibitors
  • endometrioma
  • endometrium
  • estrogen
  • letrozole
  • oral contraceptive
  • progesterone
  • progestin

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine


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