Arterial thrombosis in scleroderma

NANCY L. FUREY*, F. R. SCHMID, Hau C. Kwaan, H. H.R. FRIEDERICI

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Clinical and pathological observations are presented on five patients with scleroderma who developed Thrombosis of a major vessel. Three died following intestinal infarction or limb gangrene and two had digit or extremity amputations. Severe intimal thickening of major arteries with thrombus formation was noted but no significant abnormality was found in the clotting activity of the blood. Histochemical studies in three cases suggested a reduction of fibrinolytic activity at the site of thrombosis in the diseased vessels. These studies support the view that the vascular system is profoundly altered in scleroderma and may play an important role in some manifestations of the disease.

Original languageEnglish (US)
Pages (from-to)683-693
Number of pages11
JournalBritish Journal of Dermatology
Volume93
Issue number6
DOIs
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Dermatology

Fingerprint

Dive into the research topics of 'Arterial thrombosis in scleroderma'. Together they form a unique fingerprint.

Cite this