Artifact-free application of drugs into the avian endolymphatic space

Claus Peter Richter*, Rainer Klinke

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A push-pull system is described that allows artifact-free application of drugs into very small volumes such as, e.g., the endolymphatic space of the inner ear. The system consists of two syringes, the pistons of which are fixed together and driven by an Oriel motordrive. The syringes are connected to the pipette holders and microcapillaries by PVC tubes. One capillary is used to expel a certain volume, whilst the other one aspirates the same volume. A balanced exchange of fluids within a given space without an overall change in volume is therefore possible.

Original languageEnglish (US)
Pages (from-to)171-175
Number of pages5
JournalJournal of Neuroscience Methods
Volume51
Issue number2
DOIs
StatePublished - Mar 1994

Keywords

  • (Pigeon)
  • Cochlea
  • Drug application
  • Endolymphatic space
  • Push-Pull system

ASJC Scopus subject areas

  • Neuroscience(all)

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