TY - JOUR
T1 - Asbestos catalyzes hydroxyl and superoxide radical generation from hydrogen peroxide
AU - Weitzman, Sigmund A.
AU - Graceffa, Philip
PY - 1984/1/1
Y1 - 1984/1/1
N2 - To understand chemical characteristics of the asbestos minerals which might contribute to tissue damage, the catalytic properties of three different varieties were studied. Using spin trapping techniques it was determined that crocidolite, chrysotile, and amosite asbestos were all able to catalyze the generation of toxic hydroxyl radicals from a normal byproduct of tissue metabolism, hydrogen peroxide. The iron chelator desferroxamine inhibits this reaction, indicating a major role for iron in the catalytic process, and suggesting a possible mechanism by which asbestos toxicity might be reduced.
AB - To understand chemical characteristics of the asbestos minerals which might contribute to tissue damage, the catalytic properties of three different varieties were studied. Using spin trapping techniques it was determined that crocidolite, chrysotile, and amosite asbestos were all able to catalyze the generation of toxic hydroxyl radicals from a normal byproduct of tissue metabolism, hydrogen peroxide. The iron chelator desferroxamine inhibits this reaction, indicating a major role for iron in the catalytic process, and suggesting a possible mechanism by which asbestos toxicity might be reduced.
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U2 - 10.1016/0003-9861(84)90078-X
DO - 10.1016/0003-9861(84)90078-X
M3 - Article
C2 - 6320737
AN - SCOPUS:0021333972
VL - 228
SP - 373
EP - 376
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
SN - 0003-9861
IS - 1
ER -