Asbestos catalyzes the formation of the 6-oxobenzo[a]pyrene radical from 6-hydroxybenzo[a]pyrene

Philip Graceffa*, Sigmund A. Weitzman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Crocidolite asbestos catalyzes the oxidation of 6-hyroxybenzo[a]pyrene, a metabolite of benzo[a]pyrene, to the 6-oxobenzo[a]pyrene radical as determined by electron spin resonance spectroscopy. This may be a mechanism whereby inhaled asbestos enhances the incidence of lung cancer induced by cigarette smoke, which contains benzo[a]pyrene.

Original languageEnglish (US)
Pages (from-to)481-484
Number of pages4
JournalArchives of Biochemistry and Biophysics
Volume257
Issue number2
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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