Ashkenazi Jewish genetic disorders

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


The frequency of several genes responsible for 'single-gene' disorders and disease predispositions is higher among Ashkenazi Jews than among Sephardi Jews and non-Jews. The disparity is most likely the result of founder effect and genetic drift, rather than heterozygote advantage. The more common Mendelian Ashkenazi Jewish genetic disorders are summarized, and examples of variable expressivity and penetrance, inconsistent genotype-phenotype correlation, and potential modifiers are presented. The importance of genetic counseling in both the pre- and post-test phases of population screening is emphasized.

Original languageEnglish (US)
Pages (from-to)201-206
Number of pages6
JournalFamilial Cancer
Issue number3-4
StatePublished - Nov 24 2004


  • Ashkenazi, Jewish, Jewish disorders, population screening

ASJC Scopus subject areas

  • Genetics
  • Oncology
  • Genetics(clinical)
  • Cancer Research

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