Aspartate aminotransferase-to-platelet ratio index increases significantly 3 years prior to liver-related death in HIV-hepatitis-coinfected men

Jennifer C. Price, Eric C. Seaberg, Valentina Stosor, Mallory D. Witt, Carling D. Lellock, Chloe L. Thio

Research output: Contribution to journalLetterpeer-review

2 Scopus citations

Abstract

: The utility of longitudinal AST-to-platelet ratio index (APRI), a surrogate for hepatic fibrosis, is unknown. We compared APRI up to 9 years before liver-related death among 57 cases of viral hepatitis-infected men (91% HIV+) to matched controls. APRI was stable among controls but, among cases, increased 4.6%/year from 9 to 3 years predeath (P = 0.10) and 30%/year during the 3 years predeath (P < 0.001). Thus, rapid APRI increase may predict impending liver-related death in HIV-viral hepatitis coinfection.

Original languageEnglish (US)
Pages (from-to)2636-2638
Number of pages3
JournalAIDS (London, England)
Volume32
Issue number17
DOIs
StatePublished - Nov 13 2018

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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