Aspects of Prostaglandin Glycerol Ester Biology

Philip J. Kingsley, Carol A. Rouzer, Amanda J. Morgan, Sachin Patel, Lawrence J. Marnett*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

The Cyclooxygenase enzymes (COX-1 and COX-2) incorporate 2 molecules of O2 into arachidonic acid (AA), resulting in an array of bioactive prostaglandins. However, much work has been done showing that COX-2 will perform this reaction on several different AA-containing molecules, most importantly, the endocannabinoid 2-arachidonoylglycerol (2-AG). The products of 2-AG oxygenation, prostaglandin glycerol esters (PG-Gs), are analogous to canonical prostaglandins. This chapter reviews the literature detailing the production, metabolism, and bioactivity of these compounds, as well as their detection in intact animals.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages77-88
Number of pages12
DOIs
StatePublished - 2019
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1161
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • 2-Arachidonoyl glycerol
  • Anandamide
  • Cannabinoid
  • COX-2
  • Cyclooxygenase
  • Endocannabinoid
  • Inflammation
  • Prostaglandin
  • Prostaglandin glyceryl ester
  • Transgenic mouse

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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