Aspirin Dosing for Secondary Prevention of Atherosclerotic Cardiovascular Disease in Patients Treated With P2Y12 Inhibitors

Saket Girotra*, Amanda Stebbins, Lisa Wruck, Guillaume Marquis-Gravel, Kamal Gupta, Peter Farrehi, Catherine P. Benziger, Mark B. Effron, Jeffrey Whittle, Daniel Muñoz, Sunil Kripalani, R. David Anderson, Sandeep K. Jain, Tamar S. Polonsky, Faraz S. Ahmad, Matthew T. Roe, Russell L. Rothman, Robert A. Harrington, Adrian F. Hernandez, W. Schuyler Jones

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: The ADAPTABLE (Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-Term Effectiveness) was a large, pragmatic, randomized controlled trial that found no difference between high-versus low-dose aspirin for secondary prevention of atherosclerotic cardiovascular disease. Whether concomitant P2Y12 inhibitor therapy modifies the effect of aspirin dose on clinical events remains unclear. METHODS AND RESULTS: Participants in ADAPTABLE were stratified according to baseline use of clopidogrel or prasugrel (P2Y12 group). The primary effectiveness end point was a composite of death, myocardial infarction, or stroke; and the primary safety end point was major bleeding requiring blood transfusions. We used multivariable Cox regression to compare the relative effectiveness and safety of aspirin dose within P2Y12 and non-P2Y12 groups. Of 13 815 (91.6%) participants with available data, 3051 (22.1%) were receiving clopidogrel (2849 [93.4%]) or prasugrel (203 [6.7%]) at baseline. P2Y12 inhibitor use was associated with higher risk of the primary effectiveness end point (10.86% versus 6.31%; adjusted hazard ratio [HR], 1.40 [95% CI, 1.22–1.62]) but was not associated with bleeding (0.95% versus 0.53%; adjusted HR, 1.42 [95% CI, 0.91–2.22]). We found no interaction in the relative effectiveness and safety of high-versus low-dose aspirin by P2Y12 inhibitor use. Overall, dose switching or discontinuation was more common in the high-dose compared with low-dose aspirin group, but the pattern was not modified by P2Y12 inhibitor use. CONCLUSIONS: In this prespecified analysis of ADAPTABLE, we found that the relative effectiveness and safety of high-versus low-dose aspirin was not modified by baseline P2Y12 inhibitor use. REGISTRATION: https://www.clinical.trials.gov. Unique identifier: NCT02697916.

Original languageEnglish (US)
Article numbere030385
JournalJournal of the American Heart Association
Volume12
Issue number20
DOIs
StatePublished - Oct 17 2023

Keywords

  • aspirin
  • atherosclerotic cardiovascular disease
  • secondary prevention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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