TY - JOUR
T1 - Aspirin-Exacerbated Diseases
T2 - Advances in Asthma with Nasal Polyposis, Urticaria, Angioedema, and Anaphylaxis
AU - Stevens, Whitney
AU - Buchheit, Kathleen
AU - Cahill, Katherine N.
N1 - Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Aspirin-exacerbated diseases are important examples of drug hypersensitivities and include aspirin-exacerbated respiratory disease (AERD), aspirin- or non-steroidal anti-inflammatory drug (NSAID)-induced urticaria/angioedema, and aspirin- or NSAID-induced anaphylaxis. While each disease subtype may be distinguished by unique clinical features, the underlying mechanisms that contribute to these phenotypes are not fully understood. However, the inhibition of the cyclooxygenase-1 enzyme is thought to play a significant role. Additionally, eosinophils, mast cells, and their products, prostaglandins and leukotrienes, have been identified in the pathogenesis of AERD. Current diagnostic and treatment strategies for aspirin-exacerbated diseases remain limited, and continued research focusing on each of the unique hypersensitivity reactions to aspirin is essential. This will not only advance the understanding of these disease processes, but also lead to the subsequent development of novel therapeutics that patients who suffer from aspirin-induced reactions desperately need.
AB - Aspirin-exacerbated diseases are important examples of drug hypersensitivities and include aspirin-exacerbated respiratory disease (AERD), aspirin- or non-steroidal anti-inflammatory drug (NSAID)-induced urticaria/angioedema, and aspirin- or NSAID-induced anaphylaxis. While each disease subtype may be distinguished by unique clinical features, the underlying mechanisms that contribute to these phenotypes are not fully understood. However, the inhibition of the cyclooxygenase-1 enzyme is thought to play a significant role. Additionally, eosinophils, mast cells, and their products, prostaglandins and leukotrienes, have been identified in the pathogenesis of AERD. Current diagnostic and treatment strategies for aspirin-exacerbated diseases remain limited, and continued research focusing on each of the unique hypersensitivity reactions to aspirin is essential. This will not only advance the understanding of these disease processes, but also lead to the subsequent development of novel therapeutics that patients who suffer from aspirin-induced reactions desperately need.
KW - Anaphylaxis
KW - Angioedema
KW - Aspirin hypersensitivity
KW - Aspirin-exacerbated respiratory disease (AERD)
KW - Nasal polyposis
KW - Urticaria
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UR - http://www.scopus.com/inward/citedby.url?scp=84945177793&partnerID=8YFLogxK
U2 - 10.1007/s11882-015-0569-2
DO - 10.1007/s11882-015-0569-2
M3 - Review article
C2 - 26475526
AN - SCOPUS:84945177793
SN - 1529-7322
VL - 15
JO - Current allergy and asthma reports
JF - Current allergy and asthma reports
IS - 12
M1 - 69
ER -