Abstract
Aspirin-Exacerbated Respiratory Disease (AERD) and Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) are both characterized by the presence of chronic sinonasal inflammation and nasal polyps. Unlike in CRSwNP, AERD patients develop respiratory reactions following ingestion of COX-1 inhibitors. AERD patients also, on average, have worse upper respiratory disease with increased sinonasal symptoms, mucosal inflammation and requirements for revision sinus surgery when compared to CRSwNP patients. While no single genetic factor has been identified in either CRSwNP or AERD to date, differences in the metabolism of arachidonic acid as well as innate immune cell activation may uniquely contribute to AERD pathogenesis.
Original language | English (US) |
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Pages (from-to) | 669-680 |
Number of pages | 12 |
Journal | Immunology and Allergy Clinics of North America |
Volume | 36 |
Issue number | 4 |
DOIs | |
State | Published - Nov 1 2016 |
Funding
Funding: This work was supported by Chronic Rhinosinusitis Integrative Studies Program ( U19-AI106683 ) and by the National Institutes of Health grants T32 AI083216 , R37 HLO68546 , RO1 HL0788860 and R01 AI104733 .
Keywords
- AERD
- Aspirin-exacerbated respiratory disease
- CRSwNP
- Chronic rhinosinusitis
- Chronic rhinosinusitis with nasal polyps
- Samter disease
- Samter triad
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology