Aspirin prevents the disruption of the blood-aqueous barrier in the rabbit eye

Arthur H. Neufeld*, Lee M. Jampol, Marvin L. Sears

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

115 Scopus citations

Abstract

THE acutely traumatized mammalian eye shows an irritative response, characterized by hyperaemia of the conjunctiva and iris, miosis, disruption of the blood-aqueous barrier, and a transient increase in intraocular pressure followed by relative hypotony. One sign of the disruption of the barrier is a positive aqueous flare, with increased concentrations of blood proteins in the aqueous humour. Stimuli that elicit all or part of this response in the rabbit eye include nitrogen mustard instillation in the conjunctival sac1, subcutaneous injection of melanocyte stimulating hormone (MSH)2, stroking the iris3,4 or cornea5, infrared irradiation of the iris6, mechanical stimulation of the trigeminal nerve 7, and anterior chamber paracentesis8.

Original languageEnglish (US)
Pages (from-to)158-159
Number of pages2
JournalNature
Volume238
Issue number5360
DOIs
StatePublished - 1972

ASJC Scopus subject areas

  • General

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