Aspirin prevents the disruption of the blood-aqueous barrier in the rabbit eye

Arthur H. Neufeld; Lee M. Jampol; Marvin L. Sears

doi:10.1038/238158a0

Aspirin prevents the disruption of the blood-aqueous barrier in the rabbit eye

Arthur H. Neufeld^*, Lee M. Jampol, Marvin L. Sears

^*Corresponding author for this work

Ophthalmology

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Abstract

THE acutely traumatized mammalian eye shows an irritative response, characterized by hyperaemia of the conjunctiva and iris, miosis, disruption of the blood-aqueous barrier, and a transient increase in intraocular pressure followed by relative hypotony. One sign of the disruption of the barrier is a positive aqueous flare, with increased concentrations of blood proteins in the aqueous humour. Stimuli that elicit all or part of this response in the rabbit eye include nitrogen mustard instillation in the conjunctival sac¹, subcutaneous injection of melanocyte stimulating hormone (MSH)², stroking the iris^3,4 or cornea⁵, infrared irradiation of the iris⁶, mechanical stimulation of the trigeminal nerve ⁷, and anterior chamber paracentesis⁸.

Original language	English (US)
Pages (from-to)	158-159
Number of pages	2
Journal	Nature
Volume	238
Issue number	5360
DOIs	https://doi.org/10.1038/238158a0
State	Published - 1972

ASJC Scopus subject areas

General

Access to Document

10.1038/238158a0

Cite this

@article{7ef9c757a92647a5b0c4eb91d20a3cdb,

title = "Aspirin prevents the disruption of the blood-aqueous barrier in the rabbit eye",

abstract = "THE acutely traumatized mammalian eye shows an irritative response, characterized by hyperaemia of the conjunctiva and iris, miosis, disruption of the blood-aqueous barrier, and a transient increase in intraocular pressure followed by relative hypotony. One sign of the disruption of the barrier is a positive aqueous flare, with increased concentrations of blood proteins in the aqueous humour. Stimuli that elicit all or part of this response in the rabbit eye include nitrogen mustard instillation in the conjunctival sac1, subcutaneous injection of melanocyte stimulating hormone (MSH)2, stroking the iris3,4 or cornea5, infrared irradiation of the iris6, mechanical stimulation of the trigeminal nerve 7, and anterior chamber paracentesis8.",

author = "Neufeld, {Arthur H.} and Jampol, {Lee M.} and Sears, {Marvin L.}",

year = "1972",

doi = "10.1038/238158a0",

language = "English (US)",

volume = "238",

pages = "158--159",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "5360",

}

TY - JOUR

T1 - Aspirin prevents the disruption of the blood-aqueous barrier in the rabbit eye

AU - Neufeld, Arthur H.

AU - Jampol, Lee M.

AU - Sears, Marvin L.

PY - 1972

Y1 - 1972

N2 - THE acutely traumatized mammalian eye shows an irritative response, characterized by hyperaemia of the conjunctiva and iris, miosis, disruption of the blood-aqueous barrier, and a transient increase in intraocular pressure followed by relative hypotony. One sign of the disruption of the barrier is a positive aqueous flare, with increased concentrations of blood proteins in the aqueous humour. Stimuli that elicit all or part of this response in the rabbit eye include nitrogen mustard instillation in the conjunctival sac1, subcutaneous injection of melanocyte stimulating hormone (MSH)2, stroking the iris3,4 or cornea5, infrared irradiation of the iris6, mechanical stimulation of the trigeminal nerve 7, and anterior chamber paracentesis8.

AB - THE acutely traumatized mammalian eye shows an irritative response, characterized by hyperaemia of the conjunctiva and iris, miosis, disruption of the blood-aqueous barrier, and a transient increase in intraocular pressure followed by relative hypotony. One sign of the disruption of the barrier is a positive aqueous flare, with increased concentrations of blood proteins in the aqueous humour. Stimuli that elicit all or part of this response in the rabbit eye include nitrogen mustard instillation in the conjunctival sac1, subcutaneous injection of melanocyte stimulating hormone (MSH)2, stroking the iris3,4 or cornea5, infrared irradiation of the iris6, mechanical stimulation of the trigeminal nerve 7, and anterior chamber paracentesis8.

UR - http://www.scopus.com/inward/record.url?scp=0015518492&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015518492&partnerID=8YFLogxK

U2 - 10.1038/238158a0

DO - 10.1038/238158a0

M3 - Article

C2 - 4558458

AN - SCOPUS:0015518492

SN - 0028-0836

VL - 238

SP - 158

EP - 159

JO - Nature

JF - Nature

IS - 5360

ER -

Aspirin prevents the disruption of the blood-aqueous barrier in the rabbit eye

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this