Assembly and Organization Processes in DNA-Directed Colloidal Crystallization

Robert J. Macfarlane; Byeongdu Lee; Haley D. Hill; Andrew J. Senesi; Soenke Seifert; Chad A. Mirkin

doi:10.1201/9781003056706-54

Assembly and Organization Processes in DNA-Directed Colloidal Crystallization

Robert J. Macfarlane, Byeongdu Lee, Haley D. Hill, Andrew J. Senesi, Soenke Seifert, Chad A. Mirkin^*

^*Corresponding author for this work

Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

We present an analysis of the key steps involved in the DNA-directed assembly of nanoparticles into crystallites and polycrystalline aggregates. Additionally, the rate of crystal growth as a function of increased DNA linker length, solution temperature, and self-complementary versus non-self-complementary DNA linker strands (1-versus 2-component systems) has been studied. The data show that the crystals grow via a 3-step process: an initial “random binding” phase resulting in disordered DNA-AuNP aggregates, 940followed by localized reorganization and subsequent growth of crystalline domain size, where the resulting crystals are well-ordered at all subsequent stages of growth.

Original language	English (US)
Title of host publication	Spherical Nucleic Acids
Subtitle of host publication	Volume 3
Publisher	Jenny Stanford Publishing
Pages	939-958
Number of pages	20
Volume	3
ISBN (Electronic)	9781000092486
ISBN (Print)	9789814877237
DOIs	https://doi.org/10.1201/9781003056706-54
State	Published - Jan 1 2021

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Engineering
General Chemistry

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10.1201/9781003056706-54

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abstract = "We present an analysis of the key steps involved in the DNA-directed assembly of nanoparticles into crystallites and polycrystalline aggregates. Additionally, the rate of crystal growth as a function of increased DNA linker length, solution temperature, and self-complementary versus non-self-complementary DNA linker strands (1-versus 2-component systems) has been studied. The data show that the crystals grow via a 3-step process: an initial “random binding” phase resulting in disordered DNA-AuNP aggregates, 940followed by localized reorganization and subsequent growth of crystalline domain size, where the resulting crystals are well-ordered at all subsequent stages of growth.",

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AU - Macfarlane, Robert J.

AU - Lee, Byeongdu

AU - Hill, Haley D.

AU - Senesi, Andrew J.

AU - Seifert, Soenke

AU - Mirkin, Chad A.

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N2 - We present an analysis of the key steps involved in the DNA-directed assembly of nanoparticles into crystallites and polycrystalline aggregates. Additionally, the rate of crystal growth as a function of increased DNA linker length, solution temperature, and self-complementary versus non-self-complementary DNA linker strands (1-versus 2-component systems) has been studied. The data show that the crystals grow via a 3-step process: an initial “random binding” phase resulting in disordered DNA-AuNP aggregates, 940followed by localized reorganization and subsequent growth of crystalline domain size, where the resulting crystals are well-ordered at all subsequent stages of growth.

AB - We present an analysis of the key steps involved in the DNA-directed assembly of nanoparticles into crystallites and polycrystalline aggregates. Additionally, the rate of crystal growth as a function of increased DNA linker length, solution temperature, and self-complementary versus non-self-complementary DNA linker strands (1-versus 2-component systems) has been studied. The data show that the crystals grow via a 3-step process: an initial “random binding” phase resulting in disordered DNA-AuNP aggregates, 940followed by localized reorganization and subsequent growth of crystalline domain size, where the resulting crystals are well-ordered at all subsequent stages of growth.

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Assembly and Organization Processes in DNA-Directed Colloidal Crystallization

Abstract

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