Assessing disease onset and progression in the SOD1 mouse model of ALS

Patrick Weydt*, So Yon Hong, Michel Kliot, Thomas Möller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

164 Scopus citations

Abstract

SOD1 transgenic mice are the most widely used animal model of amyotrophic lateral sclerosis (ALS). In addition to providing valuable insights into the pathogenesis of ALS, these animals are used intensively in many laboratories as an in vivo model for investigating novel therapeutic interventions towards this devastating motor-neuron disease. Such pre-clinical studies require objective and reliable quantification of the clinical phenotype of individual mice, most importantly of the neuromuscular abnormalities. Here we compare four parameters of the clinical phenotype: motor signs, body weight, rotarod performance and paw grip endurance for their usefulness in monitoring the SOD1 mouse model. We found that paw grip endurance is a sensitive and inexpensive alternative to the widely used rotarod test.

Original languageEnglish (US)
Pages (from-to)1051-1054
Number of pages4
JournalNeuroreport
Volume14
Issue number7
StatePublished - May 1 2003

Keywords

  • Amyotrophic lateral sclerosis
  • Grip strength endurance
  • Mouse model
  • Rotarod
  • SOD1

ASJC Scopus subject areas

  • Neuroscience(all)

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